N-(Trimethylsilyl)imidazole

Base Information Edit

Chemical Name:N-(Trimethylsilyl)imidazole
CAS No.:18156-74-6
Deprecated CAS:150059-66-8
Molecular Formula:C6H12N2Si
Molecular Weight:140.26
Hs Code.:29332990
European Community (EC) Number:242-040-3
NSC Number:139860
UNII:PX8K4R8KWX
DSSTox Substance ID:DTXSID5066326
Nikkaji Number:J53.639C
Wikidata:Q27158312
ChEMBL ID:CHEMBL1565732
Mol file:18156-74-6.mol

Synonyms:Imidazole,1-(trimethylsilyl)- (6CI,7CI,8CI);(Trimethylsilyl)imidazole;1-(Trimethylsilyl)-1H-imidazole;1-(Trimethylsilyl)imidazole;1-Imidazolyltrimethylsilane;NSC 139860;TMSI;TSIM;Trimethylimidazosilane;N-(Trimethylsilyl)imidazole (TSIM);

Suppliers and Price of N-(Trimethylsilyl)imidazole

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
N-Trimethylsilylimidazole
500mg
$ 410.00

TRC
N-Trimethylsilylimidazole
10g
$ 970.00

TCI Chemical
N-Trimethylsilylimidazole Kit SIM 1 mL × 8 / Reaction vial, capacity 2 mL × 8 [Trimethylsilylating Reagent] >98.0%(T)
1kit
$ 217.00

TCI Chemical
N-Trimethylsilylimidazole [Trimethylsilylating Reagent] >98.0%(T)
100g
$ 85.00

TCI Chemical
TMS-Imidazole (=N-Trimethylsilylimidazole)[for Gas Chromatography] >98.0%(T)
5mL
$ 27.00

TCI Chemical
N-Trimethylsilylimidazole [Trimethylsilylating Reagent] >98.0%(T)
25g
$ 38.00

Soltec Ventures
N-Trimethylsilylimidazole,99% 99%
5gm
$ 28.00

Soltec Ventures
N-Trimethylsilylimidazole,99% 99%
10*1ml
$ 105.00

Sigma-Aldrich
1-(Trimethylsilyl)imidazole ≥98.0%
250ml
$ 350.00

Sigma-Aldrich
N-(Trimethylsilyl)imidazole for synthesis
100 mL
$ 196.10

Total 128 raw suppliers

Chemical Property of N-(Trimethylsilyl)imidazole Edit

Chemical Property:

Appearance/Colour:Colorless transparent liquid
Vapor Pressure:0.203mmHg at 25°C
Melting Point:-42 °C
Refractive Index:n20/D 1.475(lit.)
Boiling Point:209.4 °C at 760 mmHg
PKA:7.96±0.10(Predicted)
Flash Point:80.5 °C
PSA：17.82000
Density:0.956 g/cm³
LogP:1.56610
Storage Temp.:2-8°C
Sensitive.:Moisture Sensitive
Solubility.:Chloroform
Water Solubility.:decomposes
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:140.076974926
Heavy Atom Count:9
Complexity:97.7

Purity/Quality:

99% ^*data from raw suppliers

N-Trimethylsilylimidazole ^*data from reagent suppliers

Safty Information:

Pictogram(s): F,Xi
Hazard Codes:F,Xi,C
Statements: 11-36/37/38-14-40-34-37-35-20/21/22
Safety Statements: 16-26-33-37/39-45-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Chemical Classes:Nitrogen Compounds -> Imidazoles
Canonical SMILES:C[Si](C)(C)N1C=CN=C1
Physical properties bp 93–94 °C/14 mmHg; fp 5 °C; d 0.956 g cm?3.
Uses N-(trimethylsilyl) imidazole (TMSim) is quite reactive with hydroxyl groups in a variety of analytes including a variety of lipids.As with other derivatization reactions,microwave heating can greatly improve process efficiency. N-(Trimethylsilyl)imidazole is a silylating agent for alcohols and 1,3-dicarbonyl compounds; reaction with esters to give imidazolides; preparation of O-trimethylsilyl monothioacetals; aromatization of the A-ring of steroids. It participates in the reactions of Hydroxyl Silylation Reactions, Silyl Aminal Formation Reactions, Nitrogen Silylation Reactions, Acyl Imidazole Formation, Michael Addition Reactions, Substitution Reactions, Phosphoroimidazolidate Formation, and other uses. A general silylating agent, particularly for alcohols. An intermediate for the synthesis of imidazole derivatives. Silylating reagent for the protection of hydroxyl groups in the presence of amine functionalities.1

Technology Process of N-(Trimethylsilyl)imidazole

There total 13 articles about N-(Trimethylsilyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%