Piperacillin

Base Information Edit

Chemical Name:Piperacillin
CAS No.:61477-96-1
Molecular Formula:C₂₃H₂₇N₅O₇S
Molecular Weight:517.563
Hs Code.:2941101900
European Community (EC) Number:262-811-8,261-868-6
UNII:9I628532GX
DSSTox Substance ID:DTXSID2023482
Nikkaji Number:J18.442J
Wikipedia:Piperacillin
Wikidata:Q423787
NCI Thesaurus Code:C61891
RXCUI:1546000
Metabolomics Workbench ID:42704
ChEMBL ID:CHEMBL702
Mol file:61477-96-1.mol

Synonyms:AB Piperacillin;AB-Piperacillin;Cl 227193;Cl-227193;Cl227193;Curasan, Piperacillin;Monosodium Salt, Piperacillin;Pipcil;Pipera hameln;Pipera-hameln;Piperacillin;Piperacillin curasan;Piperacillin Fresenius;Piperacillin Hexal;Piperacillin Monosodium Salt;Piperacillin ratiopharm;Piperacillin Sodium;Piperacillin-ratiopharm;Pipercillin;Pipracil;Pipril;Salt, Piperacillin Monosodium;Sodium, Piperacillin;T 1220;T-1220;T1220

Suppliers and Price of Piperacillin

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Piperacillin
1g
$ 430.00

TRC
Piperacillin
1g
$ 145.00

TRC
Piperacillin
250mg
$ 80.00

TRC
Piperacillin
10g
$ 585.00

Matrix Scientific
Pipracil 95+%
1g
$ 405.00

Alfa Aesar
Piperacillin, 95%
1g
$ 152.00

Alfa Aesar
Piperacillin, 95%
500mg
$ 107.00

AK Scientific
Piperacillin
1g
$ 198.00

AHH
Piperacillinsodium 98%
500g
$ 380.00

Total 107 raw suppliers

Chemical Property of Piperacillin Edit

Chemical Property:

Appearance/Colour:Crystalline solid
Vapor Pressure:0Pa at 20℃
Melting Point:139-140ºC
PKA:2.44±0.50(Predicted)
PSA：181.73000
Density:1.51 g/cm³
LogP:0.35520
Storage Temp.:Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Solubility.:Freely soluble in methanol. Only sparingly soluble in aqueous so
Water Solubility.:256.8mg/L at 20℃
XLogP3:0.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:517.16311939
Heavy Atom Count:36
Complexity:982

Purity/Quality:

99.9% ^*data from raw suppliers

Piperacillin ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 42/43
Safety Statements: 36/37

MSDS Files:: SDS file from LookChem

Useful:

Chemical Classes:Other Uses -> Pharmaceuticals
Drug Classes:Antiinfective Agents
Canonical SMILES:CCN1CCN(C(=O)C1=O)C(=O)NC(C2=CC=CC=C2)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O
Isomeric SMILES:CCN1CCN(C(=O)C1=O)C(=O)N[C@H](C2=CC=CC=C2)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)O
Recent ClinicalTrials:A Clinical Trial of YH1177 in Patients With Otitis Media and Otorrhea
Recent EU Clinical Trials:Antibiotic pharmacokinetics in women with twin pregnancy
Recent NIPH Clinical Trials:None
Uses Piperacillin is a semisynthetic penicillin with wide spectrum of antimicrobial activity, particularly pseudomonas strains. It is used to treat moderate-to-severe infections due to susceptible organisms.
Therapeutic Function Antibiotic
Clinical Use Piperacillin (Pipracil) is the most generally useful of the extended-spectrum acylureidopenicillins. It is more active thanmezlocillin against susceptible strains of Gram-negativeaerobic bacilli, such as Serratia marcescens, Proteus,Enterobacter, Citrobacter spp., and P. aeruginosa.Mezlocillin, however, appears to be more active againstProvidencia spp. and K. pneumoniae. Piperacillin is alsoactive against anaerobic bacteria, especially B. fragilis andS. faecalis (enterococcus). β-Lactamase–producing strainsof these organisms are, however, resistant to piperacillin,which is hydrolyzed by S. aureus β-lactamase. The β-lactamase susceptibility of piperacillin is not absolute becauseβ-lactamase–producing, ampicillin-resistant strainsof N. gonorrhoeae and H. influenzae are susceptible topiperacillin.Piperacillin is destroyed rapidly by stomach acid; therefore,it is active only by intramuscular or intravenousadministration. The injectable form is provided as the white,crystalline, water-soluble sodium salt. Its pharmacokineticproperties are very similar to those of the other acylureidopenicillins.

Technology Process of Piperacillin

There total 6 articles about Piperacillin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.8%