Tazobactam sodium

Base Information

• Chemical Name: Tazobactam sodium
• CAS No.: 89785-84-2
• Molecular Formula: C₁₀H₁₁N₄O₅S*Na
• Molecular Weight: 322.277
• Hs Code.: 2934999090
• Mol file: 89785-84-2.mol

Synonyms:4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, sodiumsalt, (2S,3S,5R)- (9CI);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, sodium salt,[2S-(2a,3b,5a)]-;CL 307579;Tazobactam sodium;YTR 830;

Chemical Property of Tazobactam sodium

Chemical Property:

• Melting Point: 140-147oC
• Boiling Point: 707.1 °C at 760 mmHg
• Flash Point: 381.4 °C
• PSA: 133.67000
• Density: 1.92 g/cm3
• LogP: -1.83920
• Storage Temp.: Store at 0-5°C
• Solubility.: H2O: 50 mg/mL, clear, colorless
• Water Solubility.: Soluble in water.Soluble in water and methanol.

Purity/Quality:

99% ^*data from raw suppliers

Tazobactam Sodium Salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: Tazobactam sodium is a new triazolylmethyl beta-lactamase inhibitor launched in combination with the antibiotic piperacillin as tazocilline. Tazobactam sodium is active against penicillinases and wide spectrum of beta-lactamases. The combination product tazobactdpiperacillin is effective against a broad range of both Gram-positive and -negative organisms and is indicated for the treatment of lower respiratory tract, urinary tract, intra-abdominal, biliary and skin and soft tissue infections. It is expected to compete against the combination product augmentin (amoxicillidclavulanate).
• Uses: Lactamase inhibitor, used with ?lactam antibiotics to enhance their effect β-Lactamase inhibitor, used with β-lactam antibiotics to enhance their effect. A β-lactamase inhibitor and antibacterial agent Tazobactam sodium is a beta-Lactamase inhibitor, which is used with penicillinase inhibition studies and beta-lactam antibiotics to enhance their effect. It serves as an antibacterial penicillin derivative, which inhibits the action of bacterial beta-lactamases.
• Therapeutic Function: Antibiotic

Technology Process of Tazobactam sodium

There total 5 articles about Tazobactam sodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tazobactam acid (89786-04-9,115546-66-2,124995-08-0) → tazobactam sodium (89785-84-2,115546-70-8)

Guidance literature:

With water; sodium carbonate; In ethanol; at 20 ℃; for 24h; Reagent/catalyst; Time; Solvent;

Reference yield: 85.0%

tetrabutylammonium 2α-methyl-2β-(1,2,3-triazol-1-yl)methylpenam-3α-carboxylate-1,1-dioxide → tazobactam sodium (89785-84-2,115546-70-8)

Guidance literature:

With Amberlite-Na+ cation exchange resin;

Reference yield:

tazobactam acid (89786-04-9,115546-66-2,124995-08-0) + piperacillin (61477-96-1,64131-97-1) → sodium piperacillin (59703-84-3) + tazobactam sodium (89785-84-2,115546-70-8)

Guidance literature:

With sodium 2-ethylhexanoic acid; In methanol; water; isopropyl alcohol; at 0 - 35 ℃; for 2.5 - 3.25h; Product distribution / selectivity;

upstream raw materials:

(2S,3S,5R) 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-yl-methyl)-4-thia-1-azabicyclo[3.2.0]heptane2-carboxylic acid 4,4-dioxide, diphenyl methyl ester

tazobactam acid

piperacillin

Refernces

• 1、 -. "A process for preparing an injectable sterile pharmaceutical formulation containing at least piperacillin sodium and tazobactam sodium as active principles". Page/Page column 2-3. . Retrieved 2008/06/13.
• 2、 Micetich,Maiti,Spevak,Hall,Yamabe,Ishida,Tanaka,Yamazaki,Nakai,Ogawa. "Synthesis and β-lactamase inhibitory properties of 2β-[1,2,3-triazol-1-yl)methyl]-2α-methylpenam-3α-carboxylic acid 1,1-dioxide and related triazolyl derivatives". . p. 1469 - 1474. Retrieved 2007/10/02.