1-BENZYL-1H-BENZOTRIAZOLE

Base Information

• Chemical Name: 1-BENZYL-1H-BENZOTRIAZOLE
• CAS No.: 4706-43-8
• Molecular Formula: C13H11N3
• Molecular Weight: 209.25
• Hs Code.: 2933990090
• Mol file: 4706-43-8.mol

Synonyms:1-BENZYL-1H-BENZOTRIAZOLE;1-Benzyl-1H-benzo[d][1,2,3]triazole

Chemical Property of 1-BENZYL-1H-BENZOTRIAZOLE

Chemical Property:

• PSA: 30.71000
• LogP: 2.47960
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1-Benzyl-1H-1,2,3-benzotriazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BENZYL-1H-BENZOTRIAZOLE

There total 65 articles about 1-BENZYL-1H-BENZOTRIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1,2,3-Benzotriazole (95-14-7,27556-51-0) + benzyl chloride (100-44-7) → 1-benzyl-1H-benzotriazole (4706-43-8)

Guidance literature:

With N,N,N',N'',N'''-pentamethyldiethylenetriamine; potassium tert-butylate; copper(I) bromide; In toluene; at 20 ℃; for 9.5h; Inert atmosphere;

DOI:10.1021/acs.joc.1c01029

Reference yield: 93.0%

1,2,3-Benzotriazole (95-14-7,27556-51-0) + benzyl bromide (100-39-0) → 1-benzyl-1H-benzotriazole (4706-43-8)

Guidance literature:

With sodium hydroxide; In water; acetonitrile; for 48h;

DOI:10.1081/SCC-120004260

Reference yield: 92.0%

2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl trifluoromethanesulfonate (1437769-72-6) + benzyl azide (622-79-7) → 1-benzyl-1H-benzotriazole (4706-43-8)

Guidance literature:

With sec.-butyllithium; In diethyl ether; hexane; cyclohexane; at -78 - 25 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ol401140d

upstream raw materials:

1,2,3-Benzotriazole

benzyl chloride

N-benzyl-1,2-phenylenediamine

benzyl bromide

Downstream raw materials:

2-(1H-1,2,3-benzotriazol-1-yl)-1,2-diphenylethanone

1,10-Bis-benzotriazol-1-yl-1,10-diphenyl-decane-2,9-dione

phenanthridine

2-Benzotriazol-1-yl-2-phenyl-1-p-tolyl-ethanone

Refernces

• 1、 Chen, Jianyang,Zhang, Xuan,Wu, Jiajun,Wang, Rui,Lei, Chunlin,An, Yanan. "Facile one-pot synthesis of diarylacetylenes from arylaldehydes: Via an addition-double elimination process". supporting information. p. 4701 - 4705. Retrieved 2021/06/11.
• 2、 Kleoff, Merlin,Boeser, Lisa,Baranyi, Linda,Heretsch, Philipp. "Scalable Synthesis of Benzotriazoles via [3+2] Cycloaddition of Azides and Arynes in Flow". supporting information. p. 979 - 982. Retrieved 2021/01/18.