2-(1H-1,2,3-benzotriazol-1-yl)-1,2-diphenylethanone

Base Information

• Chemical Name: 2-(1H-1,2,3-benzotriazol-1-yl)-1,2-diphenylethanone
• CAS No.: 147861-19-6
• Molecular Formula: C₂₀H₁₅N₃O
• Molecular Weight: 313.359
• Mol file: 147861-19-6.mol

Synonyms:2-(1H-1,2,3-benzotriazol-1-yl)-1,2-diphenylethanone

Chemical Property of 2-(1H-1,2,3-benzotriazol-1-yl)-1,2-diphenylethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1H-1,2,3-benzotriazol-1-yl)-1,2-diphenylethanone

There total 3 articles about 2-(1H-1,2,3-benzotriazol-1-yl)-1,2-diphenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) + 1-benzyl-1H-benzotriazole (4706-43-8) → 2-(1H-1,2,3-benzotriazol-1-yl)-1,2-diphenylethanone (147861-19-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 12h;

DOI:10.1021/jo962291t

Reference yield: 49.0%

1,2,3-Benzotriazole (95-14-7,27556-51-0) + Desyl chloride (447-31-4) → 2-(1H-1,2,3-benzotriazol-1-yl)-1,2-diphenylethanone (147861-19-6)

Guidance literature:

With tetraethylammonium iodide; potassium carbonate; sodium hydroxide; In acetonitrile; for 48h; Reflux;

DOI:10.1002/ardp.201000357

Reference yield:

1-benzyl-1H-benzotriazole (4706-43-8) → 2-(1H-1,2,3-benzotriazol-1-yl)-1,2-diphenylethanone (147861-19-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; -78 deg C, 12 h; -78 deg C to RT;

upstream raw materials:

1,2,3-Benzotriazole

Desyl chloride

benzoic acid methyl ester

1-benzyl-1H-benzotriazole

Downstream raw materials:

2,4-diphenylquinazoline

diphenyl acetylene

phenyl benzyl ketone

2-(benzotriazol-1-yl)-2-phenylacetophenone p-tosylhydrazone

Refernces

• 1、 Katritzky, Alan R.,Wang, Junquan,Henderson, Scott A.. "Debenzotriazolylation of α-benzotriazolyl ketones with samarium diiodide". . p. 1567 - 1574. Retrieved 2007/10/03.
• 2、 Katritzky, Alan R.,Wu, Jing,Wrobel, Leszek,Rachwal, Stanislaw,Steel, Peter J.. "Novel Conversions of Benzotriazol-1-ylmethyl Derivatives". . p. 167 - 175. Retrieved 2007/10/02.