Desyl chloride

Base Information

• Chemical Name: Desyl chloride
• CAS No.: 447-31-4
• Deprecated CAS: 70288-34-5
• Molecular Formula: C14H11 Cl O
• Molecular Weight: 230.694
• Hs Code.: 2914 79 00
• European Community (EC) Number: 207-181-7
• NSC Number: 2883
• DSSTox Substance ID: DTXSID50870538
• Nikkaji Number: J11.380H
• Wikidata: Q69754370
• Mol file: 447-31-4.mol

Synonyms:Desyl chloride;447-31-4;2-Chloro-1,2-diphenylethanone;2-Chloro-2-phenylacetophenone;alpha-Chlorodeoxybenzoin;1,2-Diphenyl-2-chloroethanone;alpha-Chlorobenzyl phenyl ketone;2-chloro-1,2-iphenyl-Ethanone;Acetophenone, 2-chloro-2-phenyl-;NSC 2883;Ethanone, 2-chloro-1,2-diphenyl-;2-Chloro-1,2-diphenylethone;2-chloro-1,2-diphenyl-ethanone;2-chloro-1,2-diphenylethan-1-one;EINECS 207-181-7;.alpha.-Chlorodeoxybenzoin;alpha-Chloro-alpha-phenyl acetophenone;BRN 0744474;Acetophenone, alpha-chloro-alpha-phenyl-;AI3-22036;.alpha.-Chlorobenzyl phenyl ketone;Ethone, 2-chloro-1,2-diphenyl-;.alpha.-Chloro-.alpha.-phenyl acetophenone;Acetophenone, .alpha.-chloro-.alpha.-phenyl-;3-07-00-02106 (Beilstein Handbook Reference);Akos Bbs-00004804;WLN: GYR&VR;.alpha.-Chlorodesoxybenzoin;SCHEMBL458300;RXDYOLRABMJTEF-UHFFFAOYSA-;DTXSID50870538;NSC2883;2-chloro-1,2-di(phenyl)ethanone;2-Chloro-1,2-diphenylethanone #;NSC-2883;alpha-Chloro-alpha-phenylacetophenone;MFCD00000858;STL199337;AKOS000269476;AKOS016039515;BS-43811;D1745;FT-0624530;EN300-20542;D89919;AG-205/01822001;W-202790;Z104478784

Chemical Property of Desyl chloride

Chemical Property:

• Appearance/Colour: off-white to light beige powder
• Vapor Pressure: 6.14E-05mmHg at 25°C
• Melting Point: 62-63 °C(lit.)
• Refractive Index: 1.592
• Boiling Point: 345.5°Cat760mmHg
• Flash Point: 190.4°C
• PSA: 17.07000
• Density: 1.19g/cm³
• LogP: 3.84940
• Storage Temp.: Store below +30°C.
• Sensitive.: Moisture Sensitive
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 230.0498427
• Heavy Atom Count: 16
• Complexity: 227

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-2-phenylacetophenone >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34-37
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C(=O)C2=CC=CC=C2)Cl

Technology Process of Desyl chloride

There total 52 articles about Desyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-phenyl-2-phenylchloromethyl-1,3-dioxolane (3418-37-9) → Desyl chloride (447-31-4)

Guidance literature:

With boron trifluoride diethyl etherate; water; In 1,4-dioxane; at 70 ℃; for 10h;

Reference yield: 95.0%

benzil monohydrazone (5344-88-7) → Desyl chloride (447-31-4)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 20 ℃;

DOI:10.1016/j.tetlet.2006.08.120

Reference yield: 91.0%

1,2-Diphenylethanol (5773-56-8,614-29-9) → Desyl chloride (447-31-4)

Guidance literature:

With methanol; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; In dichloromethane; at 20 ℃; for 2h; Reagent/catalyst;

DOI:10.1021/ol5024568

upstream raw materials:

2,2-dichloro-1,2-diphenylethanone

2-hydroxy-2-phenylacetophenone

2-diazo-1,2-diphenylethan-1-one

ethyl 2-chloro-2-phenylacetate

Downstream raw materials:

2-(4-methyl-piperazin-1-yl)-1,2-diphenyl-ethanone

(+/-)-2r-methoxy-2,3c-diphenyl-oxirane

α-benzoylmercapto-deoxybenzoin

1,2,2-triphenylethan-1-one

Refernces

• 1、 Abdelazeem, Ahmed H.,Salama, Samir A.,Maghrabi, Ibrahim A.. "Design, Synthesis, and Anti-Inflammatory Evaluation of Novel Diphenylthiazole-Thiazolidinone Hybrids". . p. 518 - 530. Retrieved 2015.
• 2、 Bu, Jiping,Huang, Zijun,Li, Shaoke,Ma, Xiantao,Wu, Kairui,Yang, Jiusi,Yu, Renjie,Zhang, Zhenlei. "Access to α,α-dihaloacetophenones through anodic C[dbnd]C bond cleavage in enaminones". . . Retrieved 2021/12/20.
• 3、 -. "High yield preparation method of selexipag intermediate compound under middle conditions". Paragraph 0057-0058. . Retrieved 2019/03/15.