3-(3-Methoxyphenyl)-4H-chroMen-4-one

Base Information

• Chemical Name: 3-(3-Methoxyphenyl)-4H-chroMen-4-one
• CAS No.: 153000-44-3
• Molecular Formula: C16H12O3
• Molecular Weight: 252.26468
• Mol file: 153000-44-3.mol

Synonyms:3-(3-Methoxyphenyl)-4H-chroMen-4-one

Chemical Property of 3-(3-Methoxyphenyl)-4H-chroMen-4-one

Chemical Property:

• Melting Point: 78 - 79 °C
• PSA: 39.44000
• LogP: 3.46860

Purity/Quality:

97-99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-Methoxyphenyl)-4H-chroMen-4-one

There total 6 articles about 3-(3-Methoxyphenyl)-4H-chroMen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-methoxyphenylboronic acid (10365-98-7,1107579-37-2) + 3-iodo-chromen-4-one (122775-34-2) → 3-(3-methoxyphenyl)-4H-chromen-4-one (153000-44-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; benzene; for 20h; Heating;

DOI:10.1021/jm060359j

Reference yield: 86.0%

tris-(3-methoxy-phenyl)-bismuthane (95149-16-9) + 3-iodo-chromen-4-one (122775-34-2) → 3-(3-methoxyphenyl)-4H-chromen-4-one (153000-44-3)

Guidance literature:

With potassium phosphate; bis(triphenylphosphine)palladium(II)-chloride; In 1,2-dimethoxyethane; at 90 ℃; for 4h; Inert atmosphere;

DOI:10.1055/s-0029-1217959

Reference yield: 85.0%

2,3-dihydro-2-(3-methoxyphenyl)-4H-1-benzopyran-4-one (67765-54-2,93514-38-6,127179-85-5) → 3'-methoxyflavone (53906-83-5) + 3-(3-methoxyphenyl)-4H-chromen-4-one (153000-44-3)

Guidance literature:

With thallium(III) perchlorate; In water; acetonitrile; for 0.333333h; Title compound not separated from byproducts; Heating;

upstream raw materials:

2,3-dihydro-2-(3-methoxyphenyl)-4H-1-benzopyran-4-one

3-methoxyphenylboronic acid

3-iodo-chromen-4-one

(E)-3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one

Downstream raw materials:

3-(3-methoxyphenyl)chroman-4-one

C₁₈H₁₆N₂O₂

Refernces

• 1、 Nibbs, Antoinette E.,Baize, Amanda-Lauren,Herter, Rachel M.,Scheidt, Karl A.. "Catalytic asymmetric alkylation of substituted isoflavanones". supporting information; experimental part. p. 4010 - 4013. Retrieved 2009/12/05.
• 2、 Vasselin, David A.,Westwell, Andrew D.,Matthews, Charles S.,Bradshaw, Tracey D.,Stevens, Malcolm F. G.. "Structural studies on bioactive compounds. 40.1 synthesis and biological properties of fluoro-, methoxyl-, and amino-substituted 3-phenyl-4H-1-benzopyran-4-ones and a comparison of their antitumor activities with the activities of related 2-phenylbenzothiazoles". . p. 3973 - 3981. Retrieved 2007/10/03.