trans-4,5-Dichloro-4,5-diMethyl-1,3-dioxolan-2-one

Base Information

• Chemical Name: trans-4,5-Dichloro-4,5-diMethyl-1,3-dioxolan-2-one
• CAS No.: 116857-05-7
• Molecular Formula: C₅H₆Cl₂O₃
• Molecular Weight: 185.007
• Mol file: 116857-05-7.mol

Synonyms:trans-4,5-Dichloro-4,5-diMethyl-1,3-dioxolan-2-one

Chemical Property of trans-4,5-Dichloro-4,5-diMethyl-1,3-dioxolan-2-one

Chemical Property:

• Boiling Point: 252.3±30.0 °C(Predicted)
• PSA: 35.53000
• Density: 1.46±0.1 g/cm3(Predicted)
• LogP: 2.06320
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform, DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

trans-4,5-Dichloro-4,5-dimethyl-1,3-dioxolan-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: trans-4,5-Dichloro-4,5-dimethyl-1,3-dioxolan-2-one is a dioxolone derivative used in the preparation of various prodrugs.

Technology Process of trans-4,5-Dichloro-4,5-diMethyl-1,3-dioxolan-2-one

There total 3 articles about trans-4,5-Dichloro-4,5-diMethyl-1,3-dioxolan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

phosgene (75-44-5) + dimethylglyoxal (431-03-8) → trans-4,5-dichloro-4,5-dimethyl-1,3-dioxolan-2-one (116857-05-7)

Guidance literature:

With pyridine; pyridine hydrochloride; at 4 ℃; for 16h;

DOI:10.1080/00397919308009845

Reference yield: 80.0%

bis(trichloromethyl) carbonate (32315-10-9) + dimethylglyoxal (431-03-8) → trans-4,5-dichloro-4,5-dimethyl-1,3-dioxolan-2-one (116857-05-7)

Guidance literature:

With pyridine; In dichloromethane; at 10 - 20 ℃; for 3h;

Reference yield:

4,5-Dimethyl-1,3-dioxole-2-one (37830-90-3) → 4-chloromethyl-5-methyl-1,3-dioxol-2-one (80841-78-7) + 4-chloro-4-methyl-5-methylene-1,3-dioxolane-2-one (95579-71-8) + 4,5-dimethyl-4,5-dichloro-1,3-dioxolan-2-one (129482-56-0,116857-05-7)

Guidance literature:

With chlorine; In dichloromethane; at 43 - 45 ℃; Product distribution; further solvents;

upstream raw materials:

4,5-Dimethyl-1,3-dioxole-2-one

phosgene

dimethylglyoxal

bis(trichloromethyl) carbonate

Refernces

• 1、 -. "Method for synthesizing 4, 5-dimethyl-1, 3-dioxole-2-one". Paragraph 0018-0019. . Retrieved 2020/05/01.