4,5-Dimethyl-1,3-dioxol-2-one

Base Information

• Chemical Name: 4,5-Dimethyl-1,3-dioxol-2-one
• CAS No.: 37830-90-3
• Molecular Formula: C5H6O3
• Molecular Weight: 114.101
• Hs Code.: 29329990
• Mol file: 37830-90-3.mol

Synonyms:4,5-Dimethyl-2-oxo-1,3-dioxolene;4,5-Dimethyldioxol-2-one;Dimethylvinylene carbonate;4,5-Dimethyl-1,3-dioxolen-2-one;

Chemical Property of 4,5-Dimethyl-1,3-dioxol-2-one

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 17.8mmHg at 25°C
• Melting Point: 78 °C
• Refractive Index: 1.454
• Boiling Point: 117 °C at 760 mmHg
• Flash Point: 55.8 °C
• PSA: 43.35000
• Density: 1.181 g/cm³
• LogP: 0.84960
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: Chloroform, Methanol

Purity/Quality:

99.5%, ^*data from raw suppliers

4,5-Dimethyl-1,3-dioxol-2-one ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38-37-36
• Safety Statements: 26-36/37/39-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,5-Dimethyl-1,3-dioxol-2-one is a dioxolanone derivative used in the preparation of synthetic chemotherapeutic antibiotics such as Prulifloxacin (P838885).

Technology Process of 4,5-Dimethyl-1,3-dioxol-2-one

There total 11 articles about 4,5-Dimethyl-1,3-dioxol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

bis(phenyl) carbonate (102-09-0) + 2.3-butanediol (513-85-9) → 4,5-Dimethyl-1,3-dioxole-2-one (37830-90-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 2h;

Reference yield: 90.0%

bis(phenyl) carbonate (102-09-0) + 3-hydroxy-2-butanon (513-86-0,52217-02-4,51555-24-9) → 4,5-Dimethyl-1,3-dioxole-2-one (37830-90-3)

Guidance literature:

With 1,3-dimethylimidazolim iodide; potassium carbonate; In water; at 90 ℃; for 2h;

DOI:10.1002/adsc.202100870

Reference yield: 83.0%

trans-4,5-dichloro-4,5-dimethyl-1,3-dioxolan-2-one (116857-05-7) → 4,5-Dimethyl-1,3-dioxole-2-one (37830-90-3)

Guidance literature:

With acetic anhydride; zinc; In toluene; at 30 - 80 ℃; for 6h; Reagent/catalyst; Temperature; Solvent; Catalytic behavior;

upstream raw materials:

bis(trichloromethyl) carbonate

3-hydroxy-2-butanon

phosgene

carbon dioxide

Downstream raw materials:

4-bromomethyl-1,3-dioxa-5-methylcyclopentene-2-one

4-formyloxymethyl-5-methyl-1,3-dioxolen-2-one

prulifloxacin

4-hydroxymethyl-5-methyl-[1,3]dioxol-2-one

Refernces

• 1、 -. "Preparation method of olmesartan medoxomil key intermediate". Paragraph 0013-0016. . Retrieved 2021/08/07.
• 2、 Onida, Killian,Haddleton, Alice J.,Norsic, Sébastien,Boisson, Christophe,D'Agosto, Franck,Duguet, Nicolas. "Organocatalytic Synthesis of Substituted Vinylene Carbonates". supporting information. p. 5129 - 5137. Retrieved 2021/09/18.