116857-05-7 Usage
Description
trans-4,5-Dichloro-4,5-diMethyl-1,3-dioxolan-2-one is a dioxolone derivative characterized by its unique chemical structure, featuring two chlorine atoms and two methyl groups attached to a 1,3-dioxolan-2-one ring. trans-4,5-Dichloro-4,5-diMethyl-1,3-dioxolan-2-one is known for its potential applications in the pharmaceutical industry, particularly in the development of prodrugs.
Uses
Used in Pharmaceutical Industry:
trans-4,5-Dichloro-4,5-diMethyl-1,3-dioxolan-2-one is used as a key intermediate in the synthesis of various prodrugs for enhancing the bioavailability and pharmacokinetic properties of active pharmaceutical ingredients. Its unique structure allows for the formation of prodrugs that can be easily converted into their active forms in the body, improving the overall efficacy and safety of the drug.
In the preparation of prodrugs, trans-4,5-Dichloro-4,5-diMethyl-1,3-dioxolan-2-one serves as a valuable building block, enabling the development of new therapeutic agents with improved properties, such as better solubility, stability, and targeted delivery. This, in turn, contributes to the advancement of innovative drug formulations and the treatment of various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 116857-05-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,8,5 and 7 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 116857-05:
(8*1)+(7*1)+(6*6)+(5*8)+(4*5)+(3*7)+(2*0)+(1*5)=137
137 % 10 = 7
So 116857-05-7 is a valid CAS Registry Number.
116857-05-7Relevant articles and documents
The addition of phosgene to 2,3-butanedione: A facile synthetic entry into the 4,5-dichloro-1,3-dioxolan-2-one family
King Jr.
, p. 847 - 853 (1993)
The addition of phosgene to 1,2-Diketones at room temperature constitutes a facile entry into the 1,3-dioxolan-2-one family.
A Convenient and Practical Preparation of 4-Chloromethyl-5-methyl-1,3-dioxol-2-one
Ikeda, Shoji,Takebe, Yasushi,Hirayama, Ryoichi,Sakamoto, Fumio,Iuchi, Koji,Tsukamoto, Goro
, p. 394 - 397 (2007/10/02)
A new synthetic method for 4-chloromethyl-5-methyl-1,3-dioxol-2-one (1c), which is useful for preparing prodrugs, has been developed.Ene-chlorination of 4,5-dimethyl-1,3-dioxol-2-one (2) with chlorine or sulfuryl chloride afforded 4-chloro-4-methyl-5-methylene-1,3-dioxolan-2-one (3) in good yield.Compound 3 underwent allylic rearrangement to afford 1c quantitatively.The overall yield of 1c from 2 was approximately 80percent. Keywords---4-chloromethyl-5-methyl-1,3-dioxol-2-one; 4,5-dimethyl-1,3-dioxol-2-one; 4-chloro-4-methyl-5-methylene-1,3-dioxolan-2-one; ene-chlorination; allylic rearrangement; (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl group; promoiety; prodrug
