N-(2-amino-4-phenyl-1,3-thiazol-5-yl)acetamide

Base Information

• Chemical Name: N-(2-amino-4-phenyl-1,3-thiazol-5-yl)acetamide
• CAS No.: 54167-89-4
• Molecular Formula: C11H11N3OS
• Molecular Weight: 233.294
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID10358605
• Wikidata: Q82139287
• ChEMBL ID: CHEMBL1348201
• Mol file: 54167-89-4.mol

Synonyms:N-(2-amino-4-phenyl-1,3-thiazol-5-yl)acetamide;54167-89-4;N-(2-Amino-4-phenylthiazol-5-yl)acetamide;MFCD00625468;MLS000100638;Oprea1_354669;Oprea1_380078;IFLab1_000825;CHEMBL1348201;DTXSID10358605;CHEMBRDG-BB 5556106;HMS1414F11;HMS2249F24;STK747404;AKOS000266969;NS-03088;SMR000018443;N-(2-amino-4-phenyl-5-thiazolyl)acetamide;CS-0309040;EN300-153286;A830078;SR-01000508372;N-(2-azanyl-4-phenyl-1,3-thiazol-5-yl)ethanamide;SR-01000508372-1;Z276545936;N-(2-Amino-4-phenyl-1,3-thiazol-5-yl)acetamide, AldrichCPR

Chemical Property of N-(2-amino-4-phenyl-1,3-thiazol-5-yl)acetamide

Chemical Property:

• Vapor Pressure: 3.71E-09mmHg at 25°C
• Boiling Point: 474.1°C at 760 mmHg
• Flash Point: 240.6°C
• PSA: 96.25000
• Density: 1.35g/cm³
• LogP: 3.00490
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 233.06228316
• Heavy Atom Count: 16
• Complexity: 256

Purity/Quality:

99% ^*data from raw suppliers

N-(2-Amino-4-phenyl-1,3-thiazol-5-yl)acetamide Aldrich ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=C(N=C(S1)N)C2=CC=CC=C2

Technology Process of N-(2-amino-4-phenyl-1,3-thiazol-5-yl)acetamide

There total 1 articles about N-(2-amino-4-phenyl-1,3-thiazol-5-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

C11H11ClO2 + thiourea (17356-08-0) → N-(2-amino-4-phenyl-thiazol-5-yl)-acetamide (54167-89-4)

Guidance literature:

C₁₁H₁₁ClO₂; thiourea; In tetrahydrofuran; at 20 - 25 ℃; for 24h;

In methanol; for 1h; Reflux;

With water; sodium hydrogencarbonate;

DOI:10.1134/S1070363208070268

Reference yield: 76.0%

N-(2-amino-4-phenyl-thiazol-5-yl)-acetamide (54167-89-4) → 5-phenyl-2-thioxoimidazolidin-4-one (62420-76-2)

Guidance literature:

N-(2-amino-4-phenyl-thiazol-5-yl)-acetamide; With hydrogenchloride; water; In ethanol; for 2h; Reflux;

With sodium hydrogencarbonate; In ethanol; water;

DOI:10.1134/S1070363208070268

upstream raw materials:

thiourea

Downstream raw materials:

5-phenyl-2-thioxoimidazolidin-4-one

Refernces