3-(2-Methoxy-5-methylphenyl)-3-phenylpropyl methanesulfonate

Base Information

• Chemical Name: 3-(2-Methoxy-5-methylphenyl)-3-phenylpropyl methanesulfonate
• CAS No.: 882878-66-2
• Molecular Formula: C18H22O4S
• Molecular Weight: 334.436
• Mol file: 882878-66-2.mol

Synonyms:3-(2-Methoxy-5-methylphenyl)-3-phenylpropyl methanesulfonate

Chemical Property of 3-(2-Methoxy-5-methylphenyl)-3-phenylpropyl methanesulfonate

Chemical Property:

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-Methoxy-5-methylphenyl)-3-phenylpropyl methanesulfonate

There total 3 articles about 3-(2-Methoxy-5-methylphenyl)-3-phenylpropyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-(2-methoxy-5-methylphenyl)-3-phenylpropan-1-ol (124937-73-1) + methanesulfonyl chloride (124-63-0) → 3-(2-methoxy-5-methylphenyl)-3-phenylpropyl-methanesulfonate (882878-66-2)

Guidance literature:

3-(2-methoxy-5-methylphenyl)-3-phenylpropan-1-ol; methanesulfonyl chloride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 20h;

In dichloromethane; water; at 0 ℃;

Reference yield:

6-methyl-4-phenyl-3,4-dihydrocoumarin (40546-94-9) → 3-(2-methoxy-5-methylphenyl)-3-phenylpropyl-methanesulfonate (882878-66-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / methanol / 10 h / 55 - 60 °C

2: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 3 h / -5 - 5 °C / Inert atmosphere

3: triethylamine / dichloromethane / 3 h / 0 - 10 °C / Inert atmosphere

With potassium carbonate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In methanol; dichloromethane; toluene;

Reference yield:

methyl 3-(2-methoxy-5-methylphenyl)-3-phenylpropionate → 3-(2-methoxy-5-methylphenyl)-3-phenylpropyl-methanesulfonate (882878-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 3 h / -5 - 5 °C / Inert atmosphere

2: triethylamine / dichloromethane / 3 h / 0 - 10 °C / Inert atmosphere

With triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In dichloromethane; toluene;

upstream raw materials:

3-(2-methoxy-5-methylphenyl)-3-phenylpropan-1-ol

methanesulfonyl chloride

6-methyl-4-phenyl-3,4-dihydrocoumarin

Downstream raw materials:

N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propylamine L-tartrate

N,N-diisopropyl-3-(2-methoxy-5-methylphenyl)-3-phenylpropan-1-amine hydrochloride

N,N-diisopropyl-3-(2-benzyloxy-5-methylphenyl)-3-phenylpropylamine

N,N-diisopropyl-3-(2-methoxy-5-methylphenyl)-3-phenylpropan-1-amine

Refernces

• 1、 -. "IMPROVED PROCESS FOR THE PREPARATION OF (R)-2-(3-DIISOPROPYLAMINO)-1-PHENYLPROPYL)-4METHYLPHENOL AND SALTS THEREOF". Page/Page column 6. . Retrieved 2010/09/17.