Technology Process of N,N-diisopropyl-3-(2-methoxy-5-methylphenyl)-3-phenylpropan-1-amine hydrochloride
There total 4 articles about N,N-diisopropyl-3-(2-methoxy-5-methylphenyl)-3-phenylpropan-1-amine hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-(2-methoxy-5-methylphenyl)-3-phenylpropyl-methanesulfonate; diisopropylamine;
With
sodium iodide;
In
acetonitrile;
at 100 ℃;
for 4h;
Autoclave;
With
hydrogenchloride;
In
isopropylamine;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 3 h / 0 - 10 °C / Inert atmosphere
2.1: sodium iodide / acetonitrile / 4 h / 100 °C / Autoclave
2.2: Inert atmosphere
With
triethylamine; sodium iodide;
In
dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / methanol / 10 h / 55 - 60 °C
2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 3 h / -5 - 5 °C / Inert atmosphere
3.1: triethylamine / dichloromethane / 3 h / 0 - 10 °C / Inert atmosphere
4.1: sodium iodide / acetonitrile / 4 h / 100 °C / Autoclave
4.2: Inert atmosphere
With
potassium carbonate; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; sodium iodide;
In
methanol; dichloromethane; toluene; acetonitrile;