Methyl 2-(4-methoxyphenyl)-2-oxoacetate

Base Information

• Chemical Name: Methyl 2-(4-methoxyphenyl)-2-oxoacetate
• CAS No.: 32766-61-3
• Molecular Formula: C10H10O4
• Molecular Weight: 194.187
• European Community (EC) Number: 838-844-4
• Nikkaji Number: J462.951E
• Wikidata: Q104976747
• Mol file: 32766-61-3.mol

Synonyms:methyl 2-(4-methoxyphenyl)-2-oxoacetate;32766-61-3;4-Methoxy-oxo-benzeneacetic acid methyl ester;methyl 4-methoxybenzoylformate;SCHEMBL2122107;AKOS006273584;methyl2-(4-methoxyphenyl)-2-oxoacetate;4-Methoxyphenyloxoacetic acid methyl ester;AS-44210;CS-0433808;EN300-173856

Chemical Property of Methyl 2-(4-methoxyphenyl)-2-oxoacetate

Chemical Property:

• Melting Point: 54 °C
• Boiling Point: 303.2±25.0 °C(Predicted)
• PSA: 52.60000
• Density: 1.177±0.06 g/cm3(Predicted)
• LogP: 1.05090
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 194.05790880
• Heavy Atom Count: 14
• Complexity: 216

Purity/Quality:

95%-98% ^*data from raw suppliers

Methyl2-(4-methoxyphenyl)-2-oxoacetate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)C(=O)OC

Technology Process of Methyl 2-(4-methoxyphenyl)-2-oxoacetate

There total 56 articles about Methyl 2-(4-methoxyphenyl)-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl 2-diazo-2-(4-methoxypheny)acetate (22979-36-8) → 4-methoxyphenylglyoxylate methyl ester (32766-61-3)

Guidance literature:

With water; diethylazodicarboxylate; dirhodium tetraacetate; In toluene; for 4h; Heating;

DOI:10.1055/s-2006-950412

Reference yield: 95.0%

→ methyl 4-methoxybenzoate (121-98-2) + 4-methoxyphenylglyoxylate methyl ester (32766-61-3) + phenol (108-95-2,27073-41-2)

Guidance literature:

With oxygen; In methanol; at 80 - 120 ℃;

Reference yield: 95.0%

methyl-2-(tert-butylperoxy)-2-(4-methoxyphenyl)acetate → 4-methoxyphenylglyoxylate methyl ester (32766-61-3)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/ol502494h

upstream raw materials:

methanol

p-methoxybenzoylformic acid

4-methoxy-phenyl acetic acid methyl ester

4'-(methoxy)-3-hydroxyflavone

Downstream raw materials:

4-hydroxyphenylacetate

2-(4-Methoxy-phenyl)-3-methyl-but-2-enoic acid methyl ester

(Z)-O-methylisopinastric acid

(E)-4-methoxy-5-(α-methoxycarbonyl-4-methoxybenzylidene)-3-phenylfuran-2(5H)-one

Refernces

• 1、 Gao, Wen-Xia,Liu, Miao-Chang,Wu, Hua-Yue,Wu, Xiao-Yang,Zhou, Yun-Bing. "Tris(pentafluorophenyl)borane-Catalyzed Oxygen Insertion Reaction of α-Diazoesters (α-Diazoamides) with Dimethyl Sulfoxide". supporting information. . Retrieved 2022/01/19.
• 2、 Ece, Hamdiye,Tange, Yuji,Yurino, Taiga,Ohkuma, Takeshi. "Silyl Cyanopalladate-Catalyzed Friedel-Crafts-Type Cyclization Affording 3-Aryloxindole Derivatives". supporting information. p. 935 - 939. Retrieved 2021/02/22.