α-Methyl-3,4-dihydroxyphenylpropionic Acid

Base Information

• Chemical Name: α-Methyl-3,4-dihydroxyphenylpropionic Acid
• CAS No.: 53832-94-3
• Molecular Formula: C10H12O4
• Molecular Weight: 196.203
• Hs Code.: 2918290000
• Mol file: 53832-94-3.mol

Synonyms:α-Methyl-3,4-dihydroxyphenylpropionic Acid

Chemical Property of α-Methyl-3,4-dihydroxyphenylpropionic Acid

Chemical Property:

• Boiling Point: 411.4±30.0 °C(Predicted)
• PKA: 4.79±0.10(Predicted)
• PSA: 77.76000
• Density: 1.333±0.06 g/cm3(Predicted)
• LogP: 1.36100
• Storage Temp.: -20°C Freezer
• Solubility.: Dichloromethane (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slight

Purity/Quality:

98% ^*data from raw suppliers

α-Methyl-3,4-dihydroxyphenylpropionicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of Carbidopa (C175915).

Technology Process of α-Methyl-3,4-dihydroxyphenylpropionic Acid

There total 3 articles about α-Methyl-3,4-dihydroxyphenylpropionic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

S(-)-carbidopa (302-53-4,14585-65-0,28860-95-9,28875-92-5,31823-41-3) → 1-(3,4-dihydroxyphenyl)-2-propanone (2503-44-8) + 6,7-dihydroxy-3-methylcinnoline (1176784-51-2) + 3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid (53832-94-3)

Guidance literature:

With bovine myeloperoxidase; dihydrogen peroxide; In aq. buffer; at 20 ℃; pH=6; Reagent/catalyst; Catalytic behavior; Enzymatic reaction;

DOI:10.1016/j.bbagen.2018.04.007

Reference yield:

S(-)-carbidopa (302-53-4,14585-65-0,28860-95-9,28875-92-5,31823-41-3) → 6,7-dihydroxy-3-methylcinnoline (1176784-51-2) + 3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid (53832-94-3)

Guidance literature:

With mushroom tyrosinase, specifi activity 2956 U/mg; oxygen; In tetralin; for 0.5h; pH=6.8; aq. phosphate buffer;

DOI:10.1016/j.bmcl.2009.05.002

Reference yield:

→ 3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid (53832-94-3)

Guidance literature:

(-)-L-α-Hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic Acid, als Metabolit;

DOI:10.1021/jm00236a004

upstream raw materials:

S(-)-carbidopa

Refernces

• 1、 Gasowska-Bajger, Beata,Frackowiak-Wojtasek, Bozena,Koj, Sabina,Cichon, Tomasz,Smolarczyk, Ryszard,Szala, Stanislaw,Wojtasek, Hubert. "Oxidation of carbidopa by tyrosinase and its effect on murine melanoma". body text. p. 3507 - 3510. Retrieved 2010/08/06.