2-phenoxyethyl Methanesulfonate

Base Information

• Chemical Name: 2-phenoxyethyl Methanesulfonate
• CAS No.: 141482-06-6
• Molecular Formula: C9H12O4S
• Molecular Weight: 216.258
• Mol file: 141482-06-6.mol

Synonyms:2-phenoxyethyl Methanesulfonate

Chemical Property of 2-phenoxyethyl Methanesulfonate

Chemical Property:

• PSA: 60.98000
• LogP: 2.12240

Purity/Quality:

97-99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-phenoxyethyl Methanesulfonate

There total 4 articles about 2-phenoxyethyl Methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Phenoxyethanol (122-99-6,56257-90-0,9004-78-8) + methanesulfonyl chloride (124-63-0) → 1-methanesulfonyloxy-2-(phenoxy)ethane (141482-06-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 2h;

Reference yield:

phenol (108-95-2,27073-41-2) → 1-methanesulfonyloxy-2-(phenoxy)ethane (141482-06-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 3 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C

3: triethylamine / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; acetone;

DOI:10.1016/j.ejmech.2011.04.032

Reference yield:

2-Phenoxyethanol (122-99-6,56257-90-0,9004-78-8) + Methanesulfonic anhydride (7143-01-3) → 1-methanesulfonyloxy-2-(phenoxy)ethane (141482-06-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; Inert atmosphere;

DOI:10.1021/op5000489

upstream raw materials:

2-Phenoxyethanol

methanesulfonyl chloride

phenol

Methanesulfonic anhydride

Downstream raw materials:

thioacetic acid S-(2-phenoxy-ethyl ester)

1-(2-phenoxyethyl)-4-phenylpiperazine

C₃₁H₃₂BrNO₄

C₂₂H₂₄O₄

Refernces

• 1、 -. "PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION". Page/Page column 42. . Retrieved 2020/01/24.
• 2、 Fabre, Benjamin,Pícha, Jan,Vaněk, Václav,Selicharová, Irena,Chrudinová, Martina,Collinsová, Michaela,?áková, Lenka,Budě?ínsky, Milo?,Jirá?ek, Ji?í. "Synthesis and Evaluation of a Library of Trifunctional Scaffold-Derived Compounds as Modulators of the Insulin Receptor". supporting information. p. 710 - 722. Retrieved 2016/12/22.