cis-3-Hydroxy-3-Methylcyclobutanecarboxylic acid

Base Information

• Chemical Name: cis-3-Hydroxy-3-Methylcyclobutanecarboxylic acid
• CAS No.: 1384855-41-7
• Molecular Formula: C6H10O3
• Molecular Weight: 130.1418
• Hs Code.: 2916200090
• Mol file: 1384855-41-7.mol

Synonyms:cis-3-Hydroxy-3-Methylcyclobutanecarboxylic acid

Chemical Property of cis-3-Hydroxy-3-Methylcyclobutanecarboxylic acid

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

cis-3-Hydroxy-3-methylcyclobutanecarboxylic acid 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-3-Hydroxy-3-Methylcyclobutanecarboxylic acid

There total 7 articles about cis-3-Hydroxy-3-Methylcyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

3-oxocyclobutanecarboxylic acid (23761-23-1) + methylmagnesium bromide (75-16-1) → (1S,3S)-3-hydroxy-3-methylcyclobutane-1-carboxylic acid (1384855-41-7,1314970-28-9)

Guidance literature:

In tetrahydrofuran; at -55 - 22 ℃; for 7h; stereoselective reaction; Large scale;

DOI:10.1016/j.bmc.2017.07.018

Reference yield:

benzyl trans-3-hydroxy-3-methylcyclobutanecarboxylate (1303609-20-2) → (1S,3S)-3-hydroxy-3-methylcyclobutane-1-carboxylic acid (1384855-41-7,1314970-28-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; for 5h; under 1551.49 Torr;

Reference yield:

3-methylbicyclo[1.1.0]butane-1-carbonitrile (694-25-7) → 3-Hydroxy-3-methyl-cyclobutancarbonsaeure (1384855-41-7,1314970-28-9)

Guidance literature:

With potassium hydroxide;

DOI:10.1021/ja00955a020

upstream raw materials:

3-methylbicyclo[1.1.0]butane-1-carbonitrile

benzyl 3-oxocyclobutane-1-carboxylate

benzyl trans-3-hydroxy-3-methylcyclobutanecarboxylate

3-oxocyclobutanecarboxylic acid

Downstream raw materials:

SiO₂

Refernces

• 1、 -. "COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS". Page/Page column 615. . Retrieved 2015/02/02.