1-Amino-1-deoxy-D-ribitol

Base Information

• Chemical Name: 1-Amino-1-deoxy-D-ribitol
• CAS No.: 527-47-9
• Molecular Formula: C₅H₁₃NO₄
• Molecular Weight: 151.163
• Mol file: 527-47-9.mol

Synonyms:1-Amino-1-deoxy-D-ribitol;D-Ribamine;D-Ribitylamine

Chemical Property of 1-Amino-1-deoxy-D-ribitol

Chemical Property:

• PSA: 106.94000
• LogP: -2.27960

Purity/Quality:

98%min ^*data from raw suppliers

1-Amino-1-deoxy-D-ribitol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Amino-1-deoxy-D-ribitol is an intermediate in synthesizing 5-Nitroso-6-ribitylamino-2,4(1H,3H)-pyrimidinedione (N546605), an inhibitor of lumazine synthase from spinach and the fungus Magnaporthe grisea.

Technology Process of 1-Amino-1-deoxy-D-ribitol

There total 1 articles about 1-Amino-1-deoxy-D-ribitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + 1-(3-oxo-1-methyl-butylidenamino)-1-deoxy-D-ribitol → D-Ribamin (527-47-9,5657-44-3,42015-12-3,51108-70-4,54676-23-2,55700-82-8,55700-83-9,60537-18-0,69686-08-4,132881-75-5) + acetylacetone (123-54-6,81235-32-7)

Guidance literature:

at 20 ℃;

Reference yield: 86.0%

D-Ribamin (527-47-9,5657-44-3,42015-12-3,51108-70-4,54676-23-2,55700-82-8,55700-83-9,60537-18-0,69686-08-4,132881-75-5) + 4-(dibromomethyl)-5-chlorocarbonyl-2-(4-chlorophenyl)thiazole (1272385-09-7) → 4-(dibromomethyl)-2-(4-chlorophenyl)-N-(ribityl)thiazole-5-carboxamide

Guidance literature:

at 23 ℃; Inert atmosphere;

DOI:10.1021/jm1013538

Reference yield:

D-Ribamin (527-47-9,5657-44-3,42015-12-3,51108-70-4,54676-23-2,55700-82-8,55700-83-9,60537-18-0,69686-08-4,132881-75-5) → C13H20N4O6 + C13H20N4O6 + 6,7-dimethyl-8-ribityllumazine (2535-20-8,5118-16-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / water; ethanol / 24 h / 20 °C / pH 8

2: acetic acid; iron / water / 2 h / 90 °C

3: 3 h / 20 - 80 °C

With iron; acetic acid; sodium hydroxide; In ethanol; water;

DOI:10.1039/c9ob01436e

upstream raw materials:

hydrogenchloride

Downstream raw materials:

1-(4,5-dichloro-2-nitro-anilino)-1-deoxy-D-arabitol

1-(4,5-dichloro-2-nitro-anilino)-D-1-deoxy-ribitol

1-Salicylidenamino-1-deoxy-D-arabit

5-(2-nitro-anilino)-D-lyxo-pentanetetrol-(1.2.3.4)