2-Amino-3-(4-chlorophenyl)propan-1-ol

Base Information

• Chemical Name: 2-Amino-3-(4-chlorophenyl)propan-1-ol
• CAS No.: 35373-63-8
• Molecular Formula: C9H12ClNO
• Molecular Weight: 185.653
• Hs Code.: 2922199090
• European Community (EC) Number: 252-533-5
• Mol file: 35373-63-8.mol

Synonyms:2-amino-3-(4-chlorophenyl)propan-1-ol;35373-63-8;DL-4-Chlorophenylalaninol;EINECS 252-533-5;2-Amino-3-(4-chlorophenyl)-1-propanol;(1)-2-Amino-3-(p-chlorophenyl)propanol;MFCD00004733;(+/-)-2-(p-Chlorophenyl)-1-[hydroxymethyl)ethylamine;dl-p-Chlorophenylalaninol;DL-4-Chlorphenylalaninol;MFCD09751776;p-chloro-d,l-phenylalaninol;SCHEMBL652674;DL-4-Chlorophenylalaninol, 96%;(S)-b-Amino-4-chlorobenzenepropanol;MFCD20727203;AKOS009156829;AB88801;AB89480;CS-W021545;CS-13181;SY107318;SY285307;SY285313;(+-)-2-amino-3-(p-chlorophenyl)propanol;2-Amino-3-(4-chlorophenyl)-1-propanol #;FT-0689437;(R)-2-Amino-3-(4-chlorophenyl)-1-propanol;(S)-2-Amino-3-(4-chlorophenyl)-1-propanol;N10806;EN300-1983525;A874621;(+/-)-2-amino-3-(4-chloro-phenyl)-propan-1-ol;Benzenepropanol, .beta.-amino-4-chloro-, (.+/-.)-

Chemical Property of 2-Amino-3-(4-chlorophenyl)propan-1-ol

Chemical Property:

• Vapor Pressure: 3.82E-05mmHg at 25°C
• Melting Point: 80-82 °C(lit.)
• Refractive Index: 1.575
• Boiling Point: 338.4 °C at 760 mmHg
• Flash Point: 158.5 °C
• PSA: 46.25000
• Density: 1.219 g/cm³
• LogP: 1.90240
• Storage Temp.: 2-8°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 185.0607417
• Heavy Atom Count: 12
• Complexity: 124

Purity/Quality:

98%,99%, ^*data from raw suppliers

p-Chlorophenylalaninol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CC(CO)N)Cl
• Uses: DL-4-Chlorophenylalaninol may be used in chemical synthesis.

Technology Process of 2-Amino-3-(4-chlorophenyl)propan-1-ol

There total 2 articles about 2-Amino-3-(4-chlorophenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

DL-Phe(4Cl) (7424-00-2,1991-78-2) → (R,S)-2-amino-3-p-chlorophenyl-1-propanol (35373-63-8)

Guidance literature:

With sodium tetrahydroborate; iodine; In tetrahydrofuran; Reflux;

DOI:10.1055/s-2008-1078572

Reference yield:

→ (R,S)-2-amino-3-p-chlorophenyl-1-propanol (35373-63-8)

Guidance literature:

entspr. Aminosaeure;

DOI:10.1021/bi00801a032

Reference yield: 100.0%

bis(trichloromethyl) carbonate (32315-10-9) + (R,S)-2-amino-3-p-chlorophenyl-1-propanol (35373-63-8) → 4-((4'-chlorophenyl)methyl)-2-oxazolidinone

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

upstream raw materials:

DL-Phe(4Cl)

Downstream raw materials:

C₁₃H₁₄ClNO₃

(1S)-1-(4-chlorophenylmethyl)-2-hydroxyethylamine

(R)-2-amino-3-(4-chlorophenyl)propan-1-ol

4-[4-(4-chloro-benzyl)-2-oxo-oxazolidin-3-yl]-piperidine-1-carboxylic acid tert-butyl ester

Refernces