2-Desethoxy-2-hydroxy-2H-2-ethyl Candesartan Cilexetil

Base Information

• Chemical Name: 2-Desethoxy-2-hydroxy-2H-2-ethyl Candesartan Cilexetil
• CAS No.: 1185256-03-4
• Molecular Formula: C₃₃H₃₄N₆O₆
• Molecular Weight: 610.67
• Mol file: 1185256-03-4.mol

Synonyms:2-Desethoxy-2-hydroxy-2H-2-ethyl Candesartan Cilexetil;Candesartan Cilexetil N2-Ethyl AMide (2-Desethoxy-2-hydroxy-2H-2-ethyl Candesartan Cilexetil);3-[[2'-(2-Ethyl-2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-2,3-dihydro-2-oxo-1H-benzimidazole-4-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester;(RS)-1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl-3-[[2'- (2-ethyl-2H-tetrazol-5-yl)-4-biphenylyl]Methyl]-2-oxo-2,3-dihydro-1H-benziMidazole-4-carboxylate;2-Hydroxy-1-[[2'-(2-ethyl-2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-1H-BenziMidazole-7-carboxylic Acid 1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl Ester;Candesartan Cilexetil IMpurity D;Candesartan Cilexetil EP IMpurity D

Chemical Property of 2-Desethoxy-2-hydroxy-2H-2-ethyl Candesartan Cilexetil

Chemical Property:

• Melting Point: 169-171?C
• PKA: 11.24±0.30(Predicted)
• PSA: 143.48000
• Density: 1.38
• LogP: 6.11930
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

> 95% ^*data from raw suppliers

2-Desethoxy-2-hydroxy-2H-2-ethylCandesartanCilexetil ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Desethoxy-2-hydroxy-2H-2-ethyl Candesartan Cilexetil (Candesartan Cilexetil EP Impurity D) is an impurity of Candesartan Cilexetil (PHARMEUROPA). Candesartan Cilexetil Impurity D (PHARMEUROPA).

Technology Process of 2-Desethoxy-2-hydroxy-2H-2-ethyl Candesartan Cilexetil

There total 1 articles about 2-Desethoxy-2-hydroxy-2H-2-ethyl Candesartan Cilexetil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(2-ethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (914613-36-8) → 1-{[(cyclohexyloxy)carbonyl]oxy}ethyl 3-{[2'-(2-ethyl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-2-oxo-2,3-dihydro-1H-benzimidazole-4-carboxylate (1185256-03-4)

Guidance literature:

With hydrogenchloride; water; In acetone; at 75 ℃; for 6h; Heating;

DOI:10.1135/cccc2008072

upstream raw materials:

(1RS)-1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(2-ethyl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate

Refernces