BENZOOXAZOLE-2-CARBOXYLIC ACID HYDRAZIDE

Base Information

• Chemical Name: BENZOOXAZOLE-2-CARBOXYLIC ACID HYDRAZIDE
• CAS No.: 27507-90-0
• Molecular Formula: C8H7N3O2
• Molecular Weight: 177.162
• Hs Code.: 2934999090
• Mol file: 27507-90-0.mol

Synonyms:BENZOOXAZOLE-2-CARBOXYLIC ACID HYDRAZIDE;Benzo[d]oxazole-2-carbohydrazide

Chemical Property of BENZOOXAZOLE-2-CARBOXYLIC ACID HYDRAZIDE

Chemical Property:

• PSA: 81.15000
• LogP: 1.52250
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% ^*data from raw suppliers

Benzooxazole-2-carboxylicacidhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZOOXAZOLE-2-CARBOXYLIC ACID HYDRAZIDE

There total 7 articles about BENZOOXAZOLE-2-CARBOXYLIC ACID HYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

benzoxazole-2-carboxylic acid methyl ester (27383-86-4) → benzoxazole-2-carboxylic acid hydrazide (27507-90-0)

Guidance literature:

With hydrazine hydrate; In ethanol; for 8h; Reflux;

DOI:10.1016/j.cclet.2013.04.005

Reference yield: 72.0%

benzo[d]oxazole-2-carbonyl chloride (408538-63-6) → benzoxazole-2-carboxylic acid hydrazide (27507-90-0)

Guidance literature:

With hydrazine hydrate; In ethanol; for 8h; Reflux;

DOI:10.5012/jkcs.2013.57.2.221

Reference yield:

benzoxazole-2-carboxylic acid (21598-08-3) → benzoxazole-2-carboxylic acid hydrazide (27507-90-0)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / ethanol / 3 h / 20 °C

2: hydrazine hydrate / ethanol / 8 h / Reflux

With thionyl chloride; hydrazine hydrate; In ethanol;

DOI:10.5012/jkcs.2013.57.2.221

upstream raw materials:

benzoxazole-2-carboxylic acid methyl ester

2-chloro-1,3-benzoxazole

methyl 2-benzoxazolimidate

benzo[d]oxazole-2-carbonitrile

Downstream raw materials:

N'-[chloro-(4-methoxy-phenyl)-methylene]-benzooxazole-2-carbohydrazonoyl chloride

2-[5-(4-methoxy-phenyl)-4-phenyl-4H-[1,2,4]triazol-3-yl]-benzooxazole

2-(5-phenyl-[1,3,4]oxadiazol-2-yl)benzoxazole

2-(5-(4-chloro phenyl)-[1,3,4]oxadiazol-2-yl)benzoxazole

Refernces

• 1、 Vodela, Sunil,Mekala, Raghu Vardhan Reddy,Danda, Ravinder Reddy,Kodhati, Venkateshwarlu. "Design, synthesis and screening of some novel benzoxazole based 1,3,4-oxadiazoles as potential antimicrobial agents". . p. 625 - 628. Retrieved 2013/07/27.