2-Benzoxazolecarbonyl chloride (9CI)

Base Information

• Chemical Name: 2-Benzoxazolecarbonyl chloride (9CI)
• CAS No.: 408538-63-6
• Molecular Formula: C8H4 Cl N O2
• Molecular Weight: 181.578
• Mol file: 408538-63-6.mol

Synonyms:2-Benzoxazolecarbonyl chloride (9CI)

Chemical Property of 2-Benzoxazolecarbonyl chloride (9CI)

Chemical Property:

• PSA: 43.10000
• LogP: 2.20680

Purity/Quality:

99%min ^*data from raw suppliers

2-BENZOXAZOLECARBONYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Benzoxazolecarbonyl chloride (9CI)

There total 4 articles about 2-Benzoxazolecarbonyl chloride (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

benzoxazole-2-carboxylic acid (21598-08-3) → benzo[d]oxazole-2-carbonyl chloride (408538-63-6)

Guidance literature:

With thionyl chloride; In ethanol; at 20 ℃; for 4h;

DOI:10.1016/j.cclet.2013.04.005

Reference yield:

Sodium; benzooxazole-2-carboxylate → benzo[d]oxazole-2-carbonyl chloride (408538-63-6)

Guidance literature:

With oxalyl dichloride; In dichloromethane; for 3h; Ambient temperature;

Reference yield:

benzoxazole-2-carboxylic acid ethyl ester (27383-87-5) → benzo[d]oxazole-2-carbonyl chloride (408538-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 2N NaOH / methanol / 2 h / Ambient temperature

2: (COCl)2 / CH₂Cl₂ / 3 h / Ambient temperature

With sodium hydroxide; oxalyl dichloride; In methanol; dichloromethane;

upstream raw materials:

benzoxazole-2-carboxylic acid ethyl ester

benzoxazole-2-carboxylic acid

Downstream raw materials:

N-phenyl-2-benzoxazolecarboxamide

2-hydroxymethyl-benzoxazole

α-(2-benzoxazolyl)diphenylmethanol

benzoxazole-2-carboxylic acid hydrazide

Refernces

• 1、 Gadegoni, Hemalatha,Manda, Sarangapani,Rangu, Shivaprasad. "Synthesis and screening of some novel 2-[5-(Substituted phenyl)-[1,3,4]oxadiazol-2-yl]-benzoxazoles as potential antimicrobial agents". . p. 221 - 226. Retrieved 2013/07/26.