3-Fluoro-4-difluoromethoxybenzaldehyde

Base Information

• Chemical Name: 3-Fluoro-4-difluoromethoxybenzaldehyde
• CAS No.: 1214379-56-2
• Molecular Formula: C₈H₅F₃O₂
• Molecular Weight: 190.122
• Hs Code.: 2913000090
• Mol file: 1214379-56-2.mol

Synonyms:3-Fluoro-4-difluoromethoxybenzaldehyde

Chemical Property of 3-Fluoro-4-difluoromethoxybenzaldehyde

Chemical Property:

• PSA: 26.30000
• LogP: 2.23960

Purity/Quality:

98%min ^*data from raw suppliers

4-(Difluoromethoxy)-3-fluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Fluoro-4-difluoromethoxybenzaldehyde

There total 1 articles about 3-Fluoro-4-difluoromethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-fluoro-4-hydroxybenzaldehyde (405-05-0) + sodium chlorodifluoroacetate (1895-39-2) → 4-(difluoromethoxy)-3-fluorobenzaldehyde (1214379-56-2)

Guidance literature:

With sodium hydroxide; In water; N,N-dimethyl-formamide; at 95 - 100 ℃; for 2h; Temperature; Solvent;

upstream raw materials:

3-fluoro-4-hydroxybenzaldehyde

sodium chlorodifluoroacetate

Refernces

• 1、 -. "Roflumilast intermediate 3-cyclopropanecarboxylic methoxy-4-difluoro methoxylphenylboronic preparation of formic acid". Paragraph 0027; 0028; 0030. . Retrieved 2018/02/04.