N-cyclohexyl-2-methyl-benzamide

Base Information

• Chemical Name: N-cyclohexyl-2-methyl-benzamide
• CAS No.: 6641-67-4
• Molecular Formula: C14H19NO
• Molecular Weight: 217.311
• Mol file: 6641-67-4.mol

Synonyms:2-methyl-benzoic acid p-toluidide;3-Cyclohexyl-2-methylbenzamid;2-Methyl-benz-p-toluidid;N-cyclohexyl-2-methylbenzamide;2-methyl-N-(4-methylphenyl)-benzamide;2-methylbenzoic cyclohexylamide;benzamide,2-methyl-n-(4-methylphenyl);o-Toluylsaeure-p-toluidid;

Chemical Property of N-cyclohexyl-2-methyl-benzamide

Chemical Property:

• Vapor Pressure: 1.11E-05mmHg at 25°C
• Boiling Point: 370.4°Cat760mmHg
• Flash Point: 223.3°C
• PSA: 29.10000
• Density: 1.04g/cm³
• LogP: 3.44840

Purity/Quality:

99% ^*data from raw suppliers

N-cyclohexyl-2-methylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-cyclohexyl-2-methyl-benzamide

There total 8 articles about N-cyclohexyl-2-methyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

cyclohexane (110-82-7,25012-93-5) + o-Methylbenzamid (527-85-5) → N‐cyclohexyl‐2‐methylbenzamide (6641-67-4)

Guidance literature:

With di-tert-butyl peroxide; copper diacetate; 4,4'-di-tert-butyl-2,2'-bipyridine; In acetonitrile; at 25 ℃; for 12h; chemoselective reaction; Inert atmosphere; Irradiation;

DOI:10.1021/acscatal.0c01924

Reference yield: 80.0%

ortho-methylphenyl iodide (615-37-2) + dicyclohexyl-carbodiimide (538-75-0) → N‐cyclohexyl‐2‐methylbenzamide (6641-67-4)

Guidance literature:

With [1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride; magnesium chloride; zinc; In N,N-dimethyl-formamide; at 70 ℃; for 20h;

DOI:10.1002/ejoc.201501349

Reference yield: 76.0%

Cyclohexyl isocyanide (931-53-3) + ortho-methylphenyl iodide (615-37-2) → N‐cyclohexyl‐2‐methylbenzamide (6641-67-4)

Guidance literature:

ortho-methylphenyl iodide; With copper(I) oxide; 4,7-dimethoxy-1,10-phenanthroline; caesium carbonate; In water; dimethyl sulfoxide; at 20 ℃; for 0.25h; Inert atmosphere;

Cyclohexyl isocyanide; In water; dimethyl sulfoxide; at 85 ℃; for 5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2014.05.032

upstream raw materials:

2-(cyclohexylamino)-2-oxoacetic acid

cyclohexane

o-Methylbenzamid

Cyclohexyl isocyanide

Refernces

• 1、 Li, Juncheng,Wang, Ting,Zhao, Gaoyuan. "Metal-free Photocatalytic Intermolecular anti-Markovnikov Hydroamination of Unactivated Alkenes". supporting information. p. 2650 - 2654. Retrieved 2021/06/25.
• 2、 Hoang, Thanh T.,Nguyen, Hanh T.H.,Le, Tien T.,Le, Dung T.,Truong, Thanh,Phan, Nam T.S.. "Amidation via ligand-free direct oxidative C(sp3)-H/N[sbnd]H coupling with Cu-CPO-27 metal-organic framework as a recyclable heterogeneous catalyst". . p. 8241 - 8251. Retrieved 2016/11/23.