(4E)-6-[1,3-Dihydro-6-Methoxy-7-Methyl-3-oxo-4-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)oxy]-5-isobenzofuranyl]-4-Methyl-4-hexenoic Acid Methyl Ester

Base Information

• Chemical Name: (4E)-6-[1,3-Dihydro-6-Methoxy-7-Methyl-3-oxo-4-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)oxy]-5-isobenzofuranyl]-4-Methyl-4-hexenoic Acid Methyl Ester
• CAS No.: 1186295-42-0
• Molecular Formula: C₃₂H₄₀O₁₅
• Molecular Weight: 664.661
• Mol file: 1186295-42-0.mol

Synonyms:Mycophenolic acid methyl ester phenolic 6-(2,3,4,6-tetra-O-Acetyl-β-D-glucoside);Mycophenolic Acid Methyl Ester Phenolic 6-(2,3,4,6-tetra-O-Acetyl-β-D-glucoside);(4E)-6-[1,3-Dihydro-6-Methoxy-7-Methyl-3-oxo-4-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)oxy]-5-isobenzofuranyl]-4-Methyl-4-hexenoic Acid Methyl Ester;4-Hexenoic acid, 6-[1,3-dihydro-6-methoxy-7-methyl-3-oxo-4-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)oxy]-5-isobenzofuranyl]-4-methyl-, methyl ester, (4E)-

Chemical Property of (4E)-6-[1,3-Dihydro-6-Methoxy-7-Methyl-3-oxo-4-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)oxy]-5-isobenzofuranyl]-4-Methyl-4-hexenoic Acid Methyl Ester

Chemical Property:

• Melting Point: 116-117 °C
• Boiling Point: 735.9±60.0 °C(Predicted)
• PSA: 185.49000
• Density: 1.31±0.1 g/cm3(Predicted)
• LogP: 2.57790
• Solubility.: Dichloromethane

Purity/Quality:

98% ^*data from raw suppliers

MycophenolicAcidMethylEsterPhenolic6-(2,3,4,6-tetra-O-Acetyl-β-D-glucoside) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Mycophenolic Acid Methyl Ester Phenolic 6-(2,3,4,6-tetra-O-Acetyl-β-D-glucoside) can be used in the preparation of a Mycophenolic acid metabolite.

Technology Process of (4E)-6-[1,3-Dihydro-6-Methoxy-7-Methyl-3-oxo-4-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)oxy]-5-isobenzofuranyl]-4-Methyl-4-hexenoic Acid Methyl Ester

There total 1 articles about (4E)-6-[1,3-Dihydro-6-Methoxy-7-Methyl-3-oxo-4-[(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)oxy]-5-isobenzofuranyl]-4-Methyl-4-hexenoic Acid Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl mycophenolate (31858-66-9) + 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide (572-09-8) → methyl mycophenolate 7-O-(2,3,4,6-tetra-O-acetyl)-β-D-glucopyranose (1186295-42-0)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In chloroform; water; at 20 ℃;

DOI:10.1016/j.tetlet.2009.06.060

Reference yield: 98.0%

methyl mycophenolate 7-O-(2,3,4,6-tetra-O-acetyl)-β-D-glucopyranose (1186295-42-0) → mycophenolic acid 7-O-phenolic glucoside (55533-52-3)

Guidance literature:

With methanol; sodium hydroxide; In water; at 0 - 20 ℃;

DOI:10.1016/j.tetlet.2009.06.060

upstream raw materials:

methyl mycophenolate

2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide

Downstream raw materials:

mycophenolic acid 7-O-phenolic glucoside

Refernces