6,9-Difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate

Base Information Edit

Chemical Name:6,9-Difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate
CAS No.:4306-83-6
Molecular Formula:C23H28F2O7
Molecular Weight:454.468
Hs Code.:
Mol file:4306-83-6.mol

Synonyms:6,9-Difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate

Suppliers and Price of 6,9-Difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 5 raw suppliers

Chemical Property of 6,9-Difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate Edit

Chemical Property:

PSA：121.13000
LogP:1.13930

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 6,9-Difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate

There total 17 articles about 6,9-Difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.1%

: 2326-26-3
acetic acid 2-((6S,8S,9R,10S,11S,13S,14S)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15-decahydro-3H-cyclopenta[a]phenanthrene-17-yl)-2-oxo-ethyl ester

: 4306-83-6
21-acetyloxy-11β,16α,17α-trihydroxy-6α,9α-difluoro-1,4-diene-3,20-dione

Guidance literature:: With potassium permanganate; formic acid; In acetone; at -5 - 0 ℃; for 0.333333h;
DOI:10.1246/cl.170923

Reference yield: 5.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 356-12-7
fluocinonide

: 4306-83-6
21-acetyloxy-11β,16α,17α-trihydroxy-6α,9α-difluoro-1,4-diene-3,20-dione

: Acetic acid 2-oxo-2-[(5aS,5bS,8aR,9aR)-5a,7,7-trimethyl-2-(2-methyl-5-trifluoromethanesulfonyloxy-phenyl)-4,5,5a,8a,9,9a-hexahydro-3,6,8-trioxa-cyclopenta[b]-as-indacen-5b-yl]-ethyl ester

: Acetic acid 2-{(3aS,3bS,5S,7S,7aS,8aR)-7-[(S)-2-fluoro-2-(2-methyl-5-trifluoromethanesulfonyloxy-phenyl)-ethyl]-2,2,3b-trimethyl-6-oxo-5-trifluoromethanesulfonyloxy-octahydro-indeno[1,2-d][1,3]dioxol-3a-yl}-2-oxo-ethyl ester

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 3h; Product distribution; various amounts of reagents;
DOI:10.1016/S0040-4020(98)01172-7