Fluzon

Base Information

• Chemical Name: Fluzon
• CAS No.: 356-12-7
• Molecular Formula: C26H32F2O7
• Molecular Weight: 494.533
• Hs Code.: 2937220000
• NSC Number: 101791
• DSSTox Substance ID: DTXSID90859342
• Mol file: 356-12-7.mol

Synonyms:Acetonide 21-Acetate, Fluocinolone;FAPG, Fluocinonide;Fluocinolide;Fluocinolone Acetonide 21 Acetate;Fluocinolone Acetonide 21-Acetate;Fluocinonide;Fluocinonide FAPG;Klariderm;Lidemol;Lidex;Lyderm;Metosyn;Novoter;Tiamol;Topsym;Topsyn;Topsyne

Chemical Property of Fluzon

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 1.97E-16mmHg at 25°C
• Melting Point: 309 °C
• Refractive Index: 1.56
• Boiling Point: 591.1 °C at 760 mmHg
• PKA: 12.77±0.70(Predicted)
• Flash Point: 311.3 °C
• PSA: 99.13000
• Density: 1.34 g/cm³
• LogP: 2.93760
• Storage Temp.: Refrigerator
• Solubility.: DMSO: ≥19mg/mL
• Water Solubility.: 0.53mg/L(25 oC)
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 4
• Exact Mass: 494.21160968
• Heavy Atom Count: 35
• Complexity: 1070

Purity/Quality:

97%, ^*data from raw suppliers

FluocinoloneAcetonideAcetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+
• Hazard Codes: T+
• Statements: 28-63
• Safety Statements: 22-25-28-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OCC(=O)C12C(CC3C1(CC(C4(C3CC(C5=CC(=O)C=CC54C)F)F)O)C)OC(O2)(C)C
• Uses: Glucocorticoid; anti-inflammatory. Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid.
• Indications: Fluocinonide (Lidex, Lidex E, Fluonex) is a synthetic fluorinated corticosteroid.
• Therapeutic Function: Antiinflammatory, Glucocorticoid

Technology Process of Fluzon

There total 23 articles about Fluzon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

fluocinolone Acetonide (67-73-2) + acetic anhydride (108-24-7) → fluocinonide (356-12-7)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 0.0833333h;

DOI:10.1021/jo980011z

Reference yield: 98.2%

C26H31FO7 → fluocinonide (356-12-7)

Guidance literature:

With 1-ethyl-3-methylimidazole hydrogen fluoride; at 25 ℃; Reagent/catalyst; Temperature;

Reference yield: 87.3%

21-acetyloxy-11β,16α,17α-trihydroxy-6α,9α-difluoro-1,4-diene-3,20-dione (4306-83-6) + acetone (67-64-1) → fluocinonide (356-12-7)

Guidance literature:

With perchloric acid; at 25 - 30 ℃;

DOI:10.1246/cl.170923

upstream raw materials:

fluocinolone Acetonide

acetic anhydride

21-acetoxy-6α,9α-difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

anecortave

Downstream raw materials:

21-acetoxy-6α,9α-difluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione

fluocinolone Acetonide

21-acetyloxy-11β,16α,17α-trihydroxy-6α,9α-difluoro-1,4-diene-3,20-dione

Refernces

• 1、 -. "Synthetic method for preparing 16,17 ketal". Paragraph 0035-0039. . Retrieved 2020/04/06.
• 2、 Tang, Jie,Zeng, Chunling,Xie, Longyong,Wang, Jinghua,Tian, Mi,Guo, Cancheng. "Improved synthesis of fluocinolone acetonide and process research of 6α,9α-fluorination". . p. 110 - 112. Retrieved 2018/01/26.