(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride

Base Information

• Chemical Name: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride
• CAS No.: 1038924-71-8
• Molecular Formula: C18H22ClNO2
• Molecular Weight: 319.831
• Mol file: 1038924-71-8.mol

Synonyms:(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride;(2R,4S)-4-Amino-4-([1,1'-biphenyl]-4-ylmethyl)-2-methylbutanoic acid hydrochloride(1:1);LCA696 impurity;LCZ701

Chemical Property of (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride

Chemical Property:

• PSA: 63.32000
• LogP: 4.83650

Purity/Quality:

98% ,99% , ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2R,4S)-5-([1,1''-Biphenyl]-4-yl)-4-amino-2-methylpentanoic Acid Hydrochloride, is a building block used in various chemical synthesis, such as in the synthesis of Sacubitri (S080900), an antihypertensive drug.

Technology Process of (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride

There total 16 articles about (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(2R,4S)-5-(1,1'-biphenyl-4-yl)-2-methyl-4-nitropentanoic acid → (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid hydrochloride (1038924-71-8)

Guidance literature:

(2R,4S)-5-(1,1'-biphenyl-4-yl)-2-methyl-4-nitropentanoic acid; With hydrogen; In methanol; at 35 ℃; for 2h; under 3000.3 Torr;

With hydrogenchloride; In water;

Reference yield: 89.0%

C18H18O3*C3H9N → (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid hydrochloride (1038924-71-8)

Guidance literature:

With hydrogenchloride; pyridoxal 5'-phosphate; isopropylamine; In water; at 58 ℃; for 20h;

DOI:10.1021/acs.joc.0c00473

Reference yield: 80.0%

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one (1038924-70-7) → (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid hydrochloride (1038924-71-8)

Guidance literature:

With hydrogenchloride; acetic acid; for 20h; Reflux;

DOI:10.1002/jlcr.3817

upstream raw materials:

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

ethanol

(3R,5S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-methylpyrrolidin-2-one

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

Downstream raw materials:

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

(2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride

Refernces

• 1、 Teyssier, Valentin R.,Simard, José-Mathieu,Dornan, Mark H.,Tournoux, Fran?ois,DaSilva, Jean N.. "Radiosynthesis of the 11C-methyl derivative of LBQ657 for PET investigation of the neprilysin inhibitor sacubitril". . p. 65 - 71. Retrieved 2020/01/21.
• 2、 -. "BIPHENYL-SUBSTITUED 4-AMINO-BUTYRIC ACID DERIVATIVES AND THEIR USE IN THE SYNTHESIS OF NEP INHIBITORS". Page/Page column 121-122. . Retrieved 2017/03/14.