LuMefantrine Keto IMpurity

Base Information

• Chemical Name: LuMefantrine Keto IMpurity
• CAS No.: 53221-25-3
• Molecular Formula: C23H27Cl2NO2
• Molecular Weight: 420.37198
• Hs Code.: 2922509090
• Mol file: 53221-25-3.mol

Synonyms:2,7-Dichloro-4-[2-(dibutylaMino)-1-hydroxyethyl]-9H-fluoren-9-one;9-Des[(4-chlorophenyl)Methylene]-9-oxo LuMefantrine;LuMefantrine Keto IMpurity;LuMefentrine (Keto IMpurity)

Chemical Property of LuMefantrine Keto IMpurity

Chemical Property:

• Boiling Point: 568.0±50.0 °C(Predicted)
• PKA: 13.32±0.20(Predicted)
• PSA: 40.54000
• Density: 1.239±0.06 g/cm3(Predicted)
• LogP: 6.14040

Purity/Quality:

98% ^*data from raw suppliers

9-Des[(4-chlorophenyl)methylene]-9-oxoLumefantrine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An impurity of Lumefantrine (L474000) with antimalarial activity.

Technology Process of LuMefantrine Keto IMpurity

There total 7 articles about LuMefantrine Keto IMpurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-dibutylamino-1-(2,7-dichloro-9H-fluoren-4-yl)ethanol (69759-61-1) + 4-chlorobenzaldehyde (104-88-1) → 2,7-dichloro-4-[2-(dibutyl amino)-1-hydroxyethyl]-9H-fluoren-9-one (53221-25-3)

Guidance literature:

With oxygen; sodium hydroxide; In ethanol; at 23 - 70 ℃; for 6h;

DOI:10.1021/op060244p

Reference yield:

2-chloro-1-(2, 7-dichloro-9H-fluoren-4-yl) ethanol → 2,7-dichloro-4-[2-(dibutyl amino)-1-hydroxyethyl]-9H-fluoren-9-one (53221-25-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 3 h / 140 °C

2: sodium hydroxide; oxygen / ethanol / 6 h / 23 - 70 °C

With sodium tetrahydroborate; oxygen; sodium hydroxide; In ethanol;

DOI:10.1021/op060244p

Reference yield:

2,7-dichloro-9H-fluorene (7012-16-0) → 2,7-dichloro-4-[2-(dibutyl amino)-1-hydroxyethyl]-9H-fluoren-9-one (53221-25-3)

Guidance literature:

Multi-step reaction with 4 steps

1: aluminum (III) chloride / dichloromethane / -5 - 0 °C

2: sodium tetrahydroborate / ethanol / 1 h / -5 - 5 °C

3: sodium tetrahydroborate / ethanol / 3 h / 140 °C

4: sodium hydroxide; oxygen / ethanol / 6 h / 23 - 70 °C

With aluminum (III) chloride; sodium tetrahydroborate; oxygen; sodium hydroxide; In ethanol; dichloromethane;

DOI:10.1021/op060244p

upstream raw materials:

2,7-dichloro-4-oxiranyl-fluoren-9-one

dibutylamine

2-dibutylamino-1-(2,7-dichloro-9H-fluoren-4-yl)ethanol

4-chlorobenzaldehyde

Refernces

• 1、 Atkinson,Granchelli. "Antimalarials. 3. Fluorenemethanols". . p. 1009 - 1012. Retrieved 2007/10/06.