2,7-Dichlorofluorene

Base Information

• Chemical Name: 2,7-Dichlorofluorene
• CAS No.: 7012-16-0
• Molecular Formula: C13H8Cl2
• Molecular Weight: 235.113
• Hs Code.: 2942000000
• European Community (EC) Number: 676-989-3
• NSC Number: 73077
• DSSTox Substance ID: DTXSID10291088
• Nikkaji Number: J614.958H
• Wikidata: Q72466157
• Mol file: 7012-16-0.mol

Synonyms:2,7-Dichlorofluorene;7012-16-0;2,7-dichloro-9H-fluorene;9H-Fluorene, 2,7-dichloro-;2,7-dichlor-9h-fluoren;NSC73077;MFCD00032840;2,7-dichiorofluorene;Fluorene,7-dichloro-;9H-Fluorene,7-dichloro-;NCIOpen2_003558;SCHEMBL1922789;DTXSID10291088;SDPURBHAHVFTGX-UHFFFAOYSA-N;NSC-73077;AKOS015906812;CS-W012896;AS-15697;FT-0653350;J-507536

Chemical Property of 2,7-Dichlorofluorene

Chemical Property:

• Appearance/Colour: Off-white solid
• Vapor Pressure: 2.32E-05mmHg at 25°C
• Melting Point: 126-128 °C
• Refractive Index: 1.66
• Boiling Point: 370.7 °C at 760 mmHg
• Flash Point: 185.3 °C
• PSA: 0.00000
• Density: 1.365 g/cm³
• LogP: 4.56460
• Storage Temp.: Refrigerator
• XLogP3: 4.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 234.0003056
• Heavy Atom Count: 15
• Complexity: 217

Purity/Quality:

99% ^*data from raw suppliers

2,7-Dichlorofluorene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2=C(C=CC(=C2)Cl)C3=C1C=C(C=C3)Cl
• Uses: Intermediate in the production of Lumefantrine.

Technology Process of 2,7-Dichlorofluorene

There total 29 articles about 2,7-Dichlorofluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

9H-fluorene (86-73-7) → 2,7-dichloro-9H-fluorene (7012-16-0)

Guidance literature:

With hydrogenchloride; N-chloro-succinimide; In acetonitrile; Heating;

DOI:10.1055/s-1994-25668

Reference yield: 85.0%

2,7-dichlorofluorenone (6297-11-6) → 2,7-dichloro-9H-fluorene (7012-16-0)

Guidance literature:

With iodine; magnesium; In methanol; at 20 ℃; for 1h;

Reference yield: 37.0%

2,7-dichloro-3,6-di-t-butylfluorene (106112-42-9) → 2,7-dichloro-9H-fluorene (7012-16-0)

Guidance literature:

With aluminium trichloride; In benzene; at 50 ℃; for 0.5h;

DOI:10.1246/bcsj.59.97

upstream raw materials:

9H-fluorene

2,7-dichlorofluorenone

2,7,9,9-tetrachloro-9H-fluorene

methanol

Downstream raw materials:

9-(3-bromo-benzylidene)-2,7-dichloro-fluorene

9-benzylidene-2,7-dichloro-9H-fluorene

2,7-dichloro-4-[2-(dibutyl amino)-1-hydroxyethyl]-9H-fluoren-9-one

2-(2,7-dichloro-9H-fluoren-4-yl)oxirane

Refernces

• 1、 Hegde, Hemant,Nayak, Soukhyarani Gopal,Poojary, Boja,Purushotham, Nikil,Puthran, Divyaraj,Rasheed, Mohammed Shafeeulla. "Design, synthesis, molecular docking, and biological evaluation of novel selenium containing lumefantrine analogues". . . Retrieved 2020/02/04.
• 2、 -. "Recovery processing method of 2,7-dichlorofluorene reaction mother solution". Paragraph 0022-0025. . Retrieved 2018/10/19.