2-(2,7-DICHLORO-9H-FLUORENYL-4-YL)OXIRANE

Base Information

• Chemical Name: 2-(2,7-DICHLORO-9H-FLUORENYL-4-YL)OXIRANE
• CAS No.: 53221-14-0
• Molecular Formula: C15H10Cl2O
• Molecular Weight: 277.15
• Hs Code.: 2910900090
• Mol file: 53221-14-0.mol

Synonyms:2-(2,7-Dichloro-9H-fluoren-4-yl)-Oxirane

Chemical Property of 2-(2,7-DICHLORO-9H-FLUORENYL-4-YL)OXIRANE

Chemical Property:

• Appearance/Colour: white crystal powder
• Boiling Point: 442.0±45.0 °C(Predicted)
• PSA: 12.53000
• Density: 1.449±0.06 g/cm3(Predicted)
• LogP: 4.63590
• Solubility.: Chloroform, Dichloromethane

Purity/Quality:

99% ^*data from raw suppliers

5-Oxiranyl-2,7-dichlorofluorene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2,7-DICHLORO-9H-FLUORENYL-4-YL)OXIRANE

There total 5 articles about 2-(2,7-DICHLORO-9H-FLUORENYL-4-YL)OXIRANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-1-(2, 7-dichloro-9H-fluoren-4-yl) ethanol → 2-(2,7-dichloro-9H-fluoren-4-yl)oxirane (53221-14-0)

Guidance literature:

With sodium methylate; at 50 - 60 ℃;

DOI:10.1021/op060244p

Reference yield:

2,7-dichloro-9H-fluorene (7012-16-0) → 2-(2,7-dichloro-9H-fluoren-4-yl)oxirane (53221-14-0)

Guidance literature:

Multi-step reaction with 3 steps

1: aluminum (III) chloride / dichloromethane / -5 - 0 °C

2: sodium tetrahydroborate / ethanol / 1 h / -5 - 5 °C

3: sodium methylate / 50 - 60 °C

With aluminum (III) chloride; sodium tetrahydroborate; sodium methylate; In ethanol; dichloromethane;

DOI:10.1021/op060244p

Reference yield:

2-chloro-1-(2,7-dichloro-9H-fluoren-4-yl)-ethan-1-one → 2-(2,7-dichloro-9H-fluoren-4-yl)oxirane (53221-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / ethanol / 1 h / -5 - 5 °C

2: sodium methylate / 50 - 60 °C

With sodium tetrahydroborate; sodium methylate; In ethanol;

DOI:10.1021/op060244p

upstream raw materials:

2,7-dichloro-9H-fluorene

9H-fluorene

Downstream raw materials:

2-dibutylamino-1-(2,7-dichloro-9H-fluoren-4-yl)ethanol

2,7-dichloro-4-[2-(dibutyl amino)-1-hydroxyethyl]-9H-fluoren-9-one

2-dibutylamino-1-{2,7-dichloro-9-[1-(4-chlorophenyl)meth-(E)-ylidene]-9H-fluoren-4-yl}ethanol

lumefantrine

Refernces

• 1、 Hegde, Hemant,Nayak, Soukhyarani Gopal,Poojary, Boja,Purushotham, Nikil,Puthran, Divyaraj,Rasheed, Mohammed Shafeeulla. "Design, synthesis, molecular docking, and biological evaluation of novel selenium containing lumefantrine analogues". . . Retrieved 2020.
• 2、 Atkinson,Granchelli. "Antimalarials. 3. Fluorenemethanols". . p. 1009 - 1012. Retrieved 2007/10/06.