2,3,5-trichloro-4,6-difluoropyridine

Base Information

• Chemical Name: 2,3,5-trichloro-4,6-difluoropyridine
• CAS No.: 34415-31-1
• Molecular Formula: C5Cl3F2N
• Molecular Weight: 218.418
• Hs Code.: 2933399090
• Mol file: 34415-31-1.mol

Synonyms:2,3,5-Trichloro-4,6-difluoropyridine; pyridine, 2,3,5-trichloro-4,6-difluoro-

Chemical Property of 2,3,5-trichloro-4,6-difluoropyridine

Chemical Property:

• Vapor Pressure: 0.167mmHg at 25°C
• Refractive Index: 1.526
• Boiling Point: 220.5 °C at 760 mmHg
• Flash Point: 87.2 °C
• PSA: 12.89000
• Density: 1.72 g/cm³
• LogP: 3.32000
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2,3,5-Trichloro-4,6-difluoropyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,5-trichloro-4,6-difluoropyridine

There total 6 articles about 2,3,5-trichloro-4,6-difluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,4,5,6-pentachloropyridine (2176-62-7) → 2,3-Dichloro-5-chlorodifluoropyridine (34415-31-1) + 3,5-dichloro-2,4,6-trifluoropyridine (1737-93-5,259875-95-1)

Guidance literature:

With tris(dimethylamino)sulfonium trimethylsilyldifluoride; In tetrahydrofuran; tetrahydrofuran-d8; at 26 ℃; for 1h; regioselective reaction; Inert atmosphere; Glovebox;

DOI:10.1021/acs.joc.6b01656

Reference yield:

2,3,4,5,6-pentachloropyridine (2176-62-7) → 2,3-Dichloro-5-chlorodifluoropyridine (34415-31-1) + 3,5-dichloro-2,4,6-trifluoropyridine (1737-93-5,259875-95-1) + 2,3,5,6-tetrachloro-4-fluoropyridine (34415-32-2)

Guidance literature:

With tris(dimethylamino)sulfonium trimethylsilyldifluoride; In tetrahydrofuran; tetrahydrofuran-d8; at 26 ℃; for 1h; regioselective reaction; Inert atmosphere; Glovebox;

DOI:10.1021/acs.joc.6b01656

Reference yield:

2,3,4,5,6-pentachloropyridine (2176-62-7) → tetrachloro-monofluoropyridine (17717-16-7) + 2,3-Dichloro-5-chlorodifluoropyridine (34415-31-1) + 3,5-dichloro-2,4,6-trifluoropyridine (1737-93-5,259875-95-1) + 2,3,5,6-tetrachloro-4-fluoropyridine (34415-32-2)

Guidance literature:

With tris(dimethylamino)sulfonium trimethylsilyldifluoride; In tetrahydrofuran; tetrahydrofuran-d8; at 26 ℃; for 1h; regioselective reaction; Inert atmosphere; Glovebox;

DOI:10.1021/acs.joc.6b01656

upstream raw materials:

Pentafluoropyridine

3,5-dichloro-2,4,6-trifluoropyridine

potassium fluoride

2,3,4,5,6-pentachloropyridine

Downstream raw materials:

4-C₆H₅CH₂O-2-F-3,5,6-Cl₃C₅N

Refernces

• 1、 Weigert, F. J.. "POLYHALOAROMATIC EQUILIBRATIONS". . p. 33 - 42. Retrieved 2007/10/02.