N-(1-(S)-Ethoxycarbonyl-3-Phenylpropyl)-L-Alaninyl-N-Carboxyanhydride

Base Information

• Chemical Name: N-(1-(S)-Ethoxycarbonyl-3-Phenylpropyl)-L-Alaninyl-N-Carboxyanhydride
• CAS No.: 87269-99-6
• Molecular Formula: C15H19NO5
• Molecular Weight: 293.32
• Mol file: 87269-99-6.mol

Synonyms:N-(1-(S)-Ethoxycarbonyl-3-Phenylpropyl)-L-Alaninyl-N-Carboxyanhydride;N-(1-S-Carbethoxy-3-phenylpropyl)-L-alanyl-N-carboxyanhydride

Chemical Property of N-(1-(S)-Ethoxycarbonyl-3-Phenylpropyl)-L-Alaninyl-N-Carboxyanhydride

Chemical Property:

• PSA: 92.70000
• LogP: 1.64470

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(1-(S)-Ethoxycarbonyl-3-Phenylpropyl)-L-Alaninyl-N-Carboxyanhydride

There total 3 articles about N-(1-(S)-Ethoxycarbonyl-3-Phenylpropyl)-L-Alaninyl-N-Carboxyanhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(1'S,2S)-2-(1'-Methyl-2'-oxo-2'-phenylmethoxy-ethylamino)-4-oxo-4-phenyl-buttersaeure-ethylester (87269-98-5) → N-[(1S)-1-ethoxycarbonyl-3-phenyl-3-oxopropyl]-L-alanine (87269-99-6)

Guidance literature:

With sulfuric acid; hydrogen; palladium on activated charcoal; In acetic acid; for 7h; under 30002.4 Torr; Ambient temperature;

Reference yield:

ethyl 3-benzoyl acrylate (15121-89-8,20908-27-4,17450-56-5) + L-alanine lithium salt → N-[(1S)-1-ethoxycarbonyl-3-phenyl-3-oxopropyl]-L-alanine (87269-99-6)

Guidance literature:

In ethanol; water; at 0 ℃; for 0.5h;

Reference yield:

ethyl (E)-4-oxo-4-phenyl-2-butenoate (15121-89-8) → N-[(1S)-1-ethoxycarbonyl-3-phenyl-3-oxopropyl]-L-alanine (87269-99-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) 2N NaOH, 2.) N(C₂H₅)3 / 1.) methylene chloride, 2.) ethanol, 2 h

2: 90 percent / H₂, 1.6percent H₂SO₄ / 10percent Pd/C / acetic acid / 7 h / 30002.4 Torr / Ambient temperature

With sodium hydroxide; sulfuric acid; hydrogen; triethylamine; palladium on activated charcoal; In acetic acid;

upstream raw materials:

(1'S,2S)-2-(1'-Methyl-2'-oxo-2'-phenylmethoxy-ethylamino)-4-oxo-4-phenyl-buttersaeure-ethylester

ethyl (E)-4-oxo-4-phenyl-2-butenoate

ethyl 3-benzoyl acrylate

Downstream raw materials:

Ramipril

2--L-alanyl>-(1S,3S,5S)-2-azabicyclo<3.3.0>octane-3-carboxylic acid benzylester

Refernces