DesvancosaMinyl VancoMycin

Base Information

• Chemical Name: DesvancosaMinyl VancoMycin
• CAS No.: 101485-50-1
• Molecular Formula: C59H62Cl2N8O22
• Molecular Weight: 1306.09
• Mol file: 101485-50-1.mol

Synonyms:DesvancosaMinyl VancoMycin

Chemical Property of DesvancosaMinyl VancoMycin

Chemical Property:

• PKA: 2.95±0.70(Predicted)
• PSA: 486.01000
• Density: 1.70±0.1 g/cm3(Predicted)
• LogP: 2.99480

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Vancomycin (V096500) impurity.

Technology Process of DesvancosaMinyl VancoMycin

There total 5 articles about DesvancosaMinyl VancoMycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

vancomycin aglycon (82198-76-3) + diphosphoric acid 1''-β-D-[1'']glucopyranosyl ester 2-(uridin-5'-yl)ester (133-89-1,2956-16-3,7307-71-3,7349-77-1,16375-64-7,16375-65-8,16414-46-3,17012-87-2,25318-68-7,78391-94-3,99020-05-0,99945-86-5) → desvancosaminyl vancomycin (101485-50-1)

Guidance literature:

With tris(2-carboxyethyl)phosphine; glycosyltransferase GtfE; In glycerol; at 37 ℃; for 42h; Enzymatic reaction;

DOI:10.1021/ol501568t

Reference yield: 65.0%

vancomycin (1404-90-6) → desvancosaminyl vancomycin (101485-50-1)

Guidance literature:

With water; trifluoroacetic acid; at 10 ℃; for 2h;

DOI:10.1016/j.tetasy.2004.12.006

Reference yield:

vancomycin hydrochloride (1404-93-9) → desvancosaminylvancomycin (101485-50-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1021/ja00217a042

upstream raw materials:

vancomycin hydrochloride

vancomycin

vancomycin aglycon

diphosphoric acid 1''-β-D-[1'']glucopyranosyl ester 2-(uridin-5'-yl)ester

Downstream raw materials:

vancomycin

chloroorienticin B

vancomycin aglycon

Refernces

• 1、 Nakayama, Atsushi,Okano, Akinori,Feng, Yiqing,Collins, James C.,Collins, Karen C.,Walsh, Christopher T.,Boger, Dale L.. "Enzymatic glycosylation of vancomycin aglycon: Completion of a total synthesis of vancomycin and N- and C-terminus substituent effects of the aglycon substrate". . p. 3572 - 3575. Retrieved 2014.
• 2、 Guan, Dongliang,Huang, Wei,Jiao, Shang,Li, Jian,Liu, Bo,Shi, Weiwei,Tang, Feng,Xu, Lili. "Impurity Identification and Scale-Up of a Novel Glycopeptide Antibiotic". . p. 2390 - 2402. Retrieved 2021/11/01.