5-BroMo-2-chloro-4-hydroxypyridine

Base Information

• Chemical Name: 5-BroMo-2-chloro-4-hydroxypyridine
• CAS No.: 1196146-82-3
• Molecular Formula: C5H3BrClNO
• Molecular Weight: 208.44042
• Hs Code.: 2933399990
• Mol file: 1196146-82-3.mol

Synonyms:5-BroMo-2-chloro-4-hydroxypyridine;5-Bromo-2-chloropyridin-4(1H)-one

Chemical Property of 5-BroMo-2-chloro-4-hydroxypyridine

Chemical Property:

• Boiling Point: 361.1±37.0 °C(Predicted)
• PKA: 6.09±0.10(Predicted)
• PSA: 33.12000
• Density: 1.908±0.06 g/cm3(Predicted)
• LogP: 2.20310
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-Bromo-2-chloropyridin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BroMo-2-chloro-4-hydroxypyridine

There total 4 articles about 5-BroMo-2-chloro-4-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.5%

5-bromo-2-chloro-4-methoxypyridine (880870-13-3) → 5-bromo-2-chloro-pyridin-4-ol (1196146-82-3)

Guidance literature:

With hydrogen bromide; acetic acid; In water; at 100 ℃; for 4h;

Reference yield:

3,5-dibromo-2-chloropyridin-4-ol → 5-bromo-2-chloro-pyridin-4-ol (1196146-82-3)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.166667h;

Reference yield:

2-chloropyridin-4-ol (17368-12-6) → 5-bromo-2-chloro-pyridin-4-ol (1196146-82-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid; bromine / 2 h / 25 °C

2: n-butyllithium / tetrahydrofuran / 0.17 h / -78 °C

With n-butyllithium; bromine; acetic acid; In tetrahydrofuran;

upstream raw materials:

2-chloropyridin-4-ol

5-bromo-2-chloro-4-methoxypyridine

2-chloro-4-methoxy-pyridine

Downstream raw materials:

5-bromo-2-chloro-4-(difluoromethoxy)pyridine

Refernces

• 1、 -. "6-AMINOPYRIDIN-3-YL PYRAZOLES AS MODULATORS OF RORgT". . . Retrieved 2020/01/08.