N,N-diethyl-4-nitrobenzamide

Base Information

• Chemical Name: N,N-diethyl-4-nitrobenzamide
• CAS No.: 5323-47-7
• Molecular Formula: C11H14 N2 O3
• Molecular Weight: 222.244
• Hs Code.: 2924299090
• Mol file: 5323-47-7.mol

Synonyms:Benzamide, N,N-diethyl-p-nitro- (7CI,8CI);N,N-Diethyl-4-nitrobenzamide; N,N-Diethyl-p-nitrobenzamide;NSC 2768

Chemical Property of N,N-diethyl-4-nitrobenzamide

Chemical Property:

• Vapor Pressure: 3.48E-06mmHg at 25°C
• Boiling Point: 386.7°Cat760mmHg
• Flash Point: 187.6°C
• PSA: 66.13000
• Density: 1.172g/cm³
• LogP: 2.60000

Purity/Quality:

99% ^*data from raw suppliers

N,N-Diethyl-4-nitrobenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-diethyl-4-nitrobenzamide

There total 30 articles about N,N-diethyl-4-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-nitrobenzene iodide (636-98-6) + carbon monoxide (201230-82-2) + triethylamine (121-44-8) → N,N-diethyl-4-nitrobenzamide (5323-47-7)

Guidance literature:

With palladium 10% on activated carbon; oxygen; In acetonitrile; at 100 ℃; for 8h; under 4560.31 Torr; Autoclave; Green chemistry;

DOI:10.1021/acs.joc.5b02385

Reference yield: 97.0%

4-nitro-benzoyl chloride (122-04-3) + diethylamine (109-89-7) → N,N-diethyl-4-nitrobenzamide (5323-47-7)

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/anie.201704793

Reference yield: 97.0%

diethylamine (109-89-7) + 4-nitro-benzoic acid (62-23-7) → N,N-diethyl-4-nitrobenzamide (5323-47-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2005.10.068

upstream raw materials:

4-nitro-thiobenzoic acid diethylamide

4-nitro-benzoyl chloride

diethylamine

p-nitrobenzene iodide

Downstream raw materials:

4-amino-N,N-diethylbenzamide

4-(2,2,2-trifluoroethoxy)-N,N-diethylbenzamide

5-nitro-5-(5-nitro-1,3-dioxa-5-cyclohexyl)-1,3-dioxacyclohexane

N,N-Diethyl p-(5-nitro-1,3-dioxa-5-cyclohexyl)benzamide

Refernces

• 1、 Yang, Shu-Qing,Yao, Yin-Qing,Chen, Xiao-Chao,Lu, Yong,Zhao, Xiao-Li,Liu, Ye. "Pd-Catalyst Containing a Hemilabile P,C-Hybrid Ligand in Amino Dicarbonylation of Aryl Halides for Synthesis of α-Ketoamides". . p. 1032 - 1041. Retrieved 2021/05/07.
• 2、 Ebrahimi, Edris,Khalafi-Nezhad, Ali,Khalili, Dariush,Rousta, Marzieh. "CuO-decorated magnetite-reduced graphene oxide: a robust and promising heterogeneous catalyst for the oxidative amidation of methylarenes in waterviabenzylic sp3C-H activation". . p. 20007 - 20020. Retrieved 2021/11/12.