1-PhenylcyclobutanecarboxaMide

Base Information

• Chemical Name: 1-PhenylcyclobutanecarboxaMide
• CAS No.: 17380-65-3
• Molecular Formula: C11H13NO
• Molecular Weight: 175.22702
• Hs Code.: 2924299090
• Mol file: 17380-65-3.mol

Synonyms:1-PhenylcyclobutanecarboxaMide

Chemical Property of 1-PhenylcyclobutanecarboxaMide

Chemical Property:

• PSA: 44.08000
• LogP: 2.74330

Purity/Quality:

97% ^*data from raw suppliers

1-Phenylcyclobutanecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-PhenylcyclobutanecarboxaMide

There total 6 articles about 1-PhenylcyclobutanecarboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-phenylcyclobutanecarbonitrile (14377-68-5) → 1-phenylcyclobutanecarboxamide (17380-65-3)

Guidance literature:

With silver trifluoromethanesulfonate; C₃₃H₃₃ClO₇P₃Pt⁽¹⁺⁾*CF₃O₃S^(1-); In tetrahydrofuran; water; at 23 ℃; Catalytic behavior;

DOI:10.1021/acscatal.1c02254

Reference yield:

→ 1-phenylcyclobutanecarboxamide (17380-65-3)

Guidance literature:

With thionyl chloride; Erwaermen des Reaktionsgemisches mit Ammoniak in Benzol;

DOI:10.1021/ja01857a077

Reference yield:

1-phenylcyclobutane-carbonyl chloride (4620-67-1) → 1-phenylcyclobutanecarboxamide (17380-65-3)

Guidance literature:

With ammonium hydroxide;

upstream raw materials:

1-phenylcyclobutane-carbonyl chloride

1-phenylcyclobutanecarbonitrile

Downstream raw materials:

2-phenyl-1-pyrroline

1-phenylcyclobutyl amine

<(1-Phenylcyclobutyl)carbonyl>carbamsaeureethylester

<(1-Phenylcyclobutyl)carbonyl>carbamsaeuremethylester

Refernces

• 1、 Li, Chengcheng,Chang, Xiao-Yong,Huo, Luqiong,Tan, Haibo,Xing, Xiangyou,Xu, Chen. "Hydration of Cyanohydrins by Highly Active Cationic Pt Catalysts: Mechanism and Scope". . p. 8716 - 8726. Retrieved 2021/07/26.