2,5-Dimethoxyamphetamine

Base Information

• Chemical Name: 2,5-Dimethoxyamphetamine
• CAS No.: 2801-68-5
• Deprecated CAS: 13641-74-2
• Molecular Formula: C11H17 N O2
• Molecular Weight: 195.261
• Hs Code.: 2922299090
• European Community (EC) Number: 220-540-2
• UNII: OIM1536TQQ
• DSSTox Substance ID: DTXSID2091540
• Nikkaji Number: J46.485F
• Wikidata: Q27092772
• Metabolomics Workbench ID: 146120
• ChEMBL ID: CHEMBL8642
• Mol file: 2801-68-5.mol

Synonyms:1-(2,5-dimethoxyphenyl)-2-aminopropane;2,5-dimethoxyamphetamine;2,5-dimethoxyamphetamine hydrochloride;2,5-dimethoxyamphetamine hydrochloride (+-)-isomer;2,5-dimethoxyamphetamine hydrochloride, (R)-isomer;2,5-dimethoxyamphetamine hydrochloride, (S)-isomer;2,5-dimethoxyamphetamine oxalate(1:1), (+-)-isomer;2,5-dimethoxyamphetamine sulfate(2:1);2,5-dimethoxyamphetamine, (+-)-isomer;2,5-dimethoxyamphetamine, (R)-isomer;2,5-dimethoxyamphetamine, (S)-isomer

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Chemical Property of 2,5-Dimethoxyamphetamine

Chemical Property:

• Refractive Index: 1.5718 (estimate)
• Boiling Point: 350.94°C (rough estimate)
• PKA: 9.76±0.10(Predicted)
• Flash Point: 145.2oC
• PSA: 44.48000
• Density: 1.1240 (rough estimate)
• LogP: 2.29380
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 195.125928785
• Heavy Atom Count: 14
• Complexity: 163

Purity/Quality:

Safty Information:

• Hazard Codes: T
• Statements: 23/24/25
• Safety Statements: 36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(CC1=C(C=CC(=C1)OC)OC)N
• Uses: Amphetamine derivative. Hallucinogenic.

Technology Process of 2,5-Dimethoxyamphetamine

There total 14 articles about 2,5-Dimethoxyamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

benzothiazole-2-sulfonic acid [2-(2,5-dimethoxy-phenyl)-1-methyl-ethyl]-amide → 2,5-dimethoxyphenylisopropylamine (2801-68-5)

Guidance literature:

With thiophenol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1016/S0040-4039(98)02107-8

Reference yield: 90.0%

2-(β-tosyloxypropyl)-1,4-dimethoxybenzene (77404-73-0) → 2,5-dimethoxyphenylisopropylamine (2801-68-5)

Guidance literature:

With ammonia; at 50 - 60 ℃; for 8h;

Reference yield: 70.0%

2-(β-benzenesulfonyloxypropyl)-1,4-dimethoxybenzene (262603-22-5) → 2,5-dimethoxyphenylisopropylamine (2801-68-5)

Guidance literature:

With ammonia;

upstream raw materials:

3-(2,5-dimethoxy-phenyl)-2-methyl-propionic acid amide

(E)-1,4-dimethoxy-2-(2-nitroprop-1-en-1-yl) benzene

Nitroethane

2,5-dimethoxybenzaldehyde

Downstream raw materials:

N-propionyl-1-(2,5-dimethoxyphenyl)-2-aminopropane

(-)-DMA

(S)-2-(2,5-dimethoxy-phenyl)-1-methyl-ethylamine

1-(4-benzyl-2,5-dimethoxyphenyl)-2-aminopropane

Refernces

• 1、 -. "Immunoassay for Phenethylamines of the 2C and DO Sub-Families". . . Retrieved 2015/02/19.
• 2、 Wuts, Peter G. M.,Gu, Rui Lin,Northuis, Jill M.,Thomas, Collette L.. "A new method for deprotection of benzothiazolesulfonamides using a thiol and base". . p. 9155 - 9156. Retrieved 2007/10/03.