(+)-2,5-Dimethoxyamphetamine

Base Information

• Chemical Name: (+)-2,5-Dimethoxyamphetamine
• CAS No.: 58993-80-9
• Molecular Formula: C₁₁H₁₇NO₂
• Molecular Weight: 195.261
• UNII: 2YA99BY3PT
• ChEMBL ID: CHEMBL3301866
• DSSTox Substance ID: DTXSID80872984
• Nikkaji Number: J358.857B
• Wikidata: Q63409377
• Mol file: 58993-80-9.mol

Synonyms:(+)-2,5-Dimethoxyamphetamine;2YA99BY3PT;(S)-2,5-Dimethoxyamphetamine;2,5-Dimethoxyamphetamine, (S)-;2,5-Dma, (S)-;UNII-2YA99BY3PT;58993-80-9;(2S)-1-(2,5-dimethoxyphenyl)propan-2-amine;(alphaS)-2,5-Dimethoxy-alpha-methylbenzeneethanamine;Benzeneethanamine, 2,5-dimethoxy-alpha-methyl-, (alphaS)-;NCGC00247700-01;2,5-Dimethoxy amphetamine;SCHEMBL3460220;CHEMBL3301866;DTXSID80872984;NS00068682;Q63409377;(.ALPHA.S)-2,5-DIMETHOXY-.ALPHA.-METHYLBENZENEETHANAMINE;BENZENEETHANAMINE, 2,5-DIMETHOXY-.ALPHA.-METHYL-, (.ALPHA.S)-

Chemical Property of (+)-2,5-Dimethoxyamphetamine

Chemical Property:

• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 195.125928785
• Heavy Atom Count: 14
• Complexity: 163

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(CC1=C(C=CC(=C1)OC)OC)N
• Isomeric SMILES: C[C@@H](CC1=C(C=CC(=C1)OC)OC)N

Technology Process of (+)-2,5-Dimethoxyamphetamine

There total 8 articles about (+)-2,5-Dimethoxyamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H15N3O2 (1188412-75-0) → (S)-2-(2,5-dimethoxy-phenyl)-1-methyl-ethylamine (58993-80-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 3h;

Reference yield:

[(S)-2-(2,5-Dimethoxy-phenyl)-1-methyl-ethyl]-((S)-1-phenyl-ethyl)-amine; hydrochloride → (S)-2-(2,5-dimethoxy-phenyl)-1-methyl-ethylamine (58993-80-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; water;

DOI:10.1021/jm00263a013

Reference yield:

C12H18O5S (1188412-74-9) → (S)-2-(2,5-dimethoxy-phenyl)-1-methyl-ethylamine (58993-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 2 h / 80 °C

2: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h

With sodium azide; hydrogen; palladium 10% on activated carbon; In ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

2,5-dimethoxyphenylisopropylamine

C₁₁H₁₅N₃O₂

(R)-1-(2,5-dimethoxyphenyl)propan-2-ol

C₁₂H₁₈O₅S

Downstream raw materials:

(+)-Brolamfetamine

Refernces

• 1、 -. "Asymmetric synthesis of phenylisopropylamines". . . Retrieved 2008/06/13.