1-(4-methoxyphenyl)-2-(methylamino)ethanone hydrochloride

Base Information

• Chemical Name: 1-(4-methoxyphenyl)-2-(methylamino)ethanone hydrochloride
• CAS No.: 29705-80-4
• Molecular Formula: C10H14ClNO2
• Molecular Weight: 215.68
• Mol file: 29705-80-4.mol

Synonyms:1-(4-methoxyphenyl)-2-(methylamino)ethanone hydrochloride

Chemical Property of 1-(4-methoxyphenyl)-2-(methylamino)ethanone hydrochloride

Chemical Property:

• PSA: 38.33000
• LogP: 2.29020

Purity/Quality:

95% ^*data from raw suppliers

1-(4-Methoxyphenyl)-2-(methylamino)ethanonehydrochloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-methoxyphenyl)-2-(methylamino)ethanone hydrochloride

There total 5 articles about 1-(4-methoxyphenyl)-2-(methylamino)ethanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

→ 1-(4-methoxyphenyl)-2-(methylamino)ethan-1-one hydrochloride (29705-80-4)

Guidance literature:

With methanol; acetyl chloride; for 1h;

Reference yield: 59.0%

methylamine (74-89-5) + 2-Bromo-4'-methoxyacetophenone (2632-13-5) → 1-(4-methoxyphenyl)-2-(methylamino)ethan-1-one hydrochloride (29705-80-4)

Guidance literature:

methylamine; 2-Bromo-4'-methoxyacetophenone; In ethanol; dichloromethane; acetonitrile; at -30 ℃; for 0.166667h;

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 0.0833333h;

DOI:10.1021/acs.jafc.6b01415

Reference yield:

1,2-dimethoxybenzene (91-16-7) + 2-(methylamino)acetonitrile hydrochloride (25808-30-4) → 1-(4-methoxyphenyl)-2-(methylamino)ethan-1-one hydrochloride (29705-80-4) + 1-(3,4-dimethoxy-phenyl)-2-methylamino-ethanone; hydrochloride (40511-15-7)

Guidance literature:

1,2-dimethoxybenzene; 2-(methylamino)acetonitrile hydrochloride; With hydrogenchloride; methoxybenzene; aluminum (III) chloride; In nitrobenzene; at 25 ℃; for 6h; Houben-Hoesch reaction;

With water; In nitrobenzene; at 75 ℃; Product distribution / selectivity;

upstream raw materials:

methylamine

2-Bromo-4'-methoxyacetophenone

1,2-dimethoxybenzene

2-(methylamino)acetonitrile hydrochloride

Downstream raw materials:

N-Methyl-4-methoxyphenylethylamine hydrochloride

<2-(3,4-dimethoxyphenyl)ethyl>methylamine hydrochloride

4-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-ylamine

Refernces

• 1、 -. "Polycarpine derivatives, synthesis of derivatives and application of derivatives in control of plant viruses and pathogenic bacteria". Paragraph 0038; 0039; 0040; 0041;. . Retrieved 2018/01/04.
• 2、 -. "PROCESS FOR PREPARING N-METHYL-3, 4-DIMETHOXYPHENYLETHYLAMINE". Page/Page column 7. . Retrieved 2009/07/17.