4-Iodo-3-methoxyaniline

Base Information

• Chemical Name: 4-Iodo-3-methoxyaniline
• CAS No.: 1112840-98-8
• Molecular Formula: C₇H₈INO
• Molecular Weight: 249.051
• Hs Code.: 2921490090
• Mol file: 1112840-98-8.mol

Synonyms:4-Iodo-3-methoxyaniline;4-Iodo-3-methoxy-phenylamine

Chemical Property of 4-Iodo-3-methoxyaniline

Chemical Property:

• Boiling Point: 315.7±32.0 °C(Predicted)
• PKA: 3.38±0.10(Predicted)
• PSA: 35.25000
• Density: 1.807±0.06 g/cm3(Predicted)
• LogP: 2.46320
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Iodo-3-methoxyaniline 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Iodo-3-methoxyaniline

There total 3 articles about 4-Iodo-3-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

m-Anisidine (536-90-3,918666-97-4) → 4,6-diiodo-3-methoxyaniline (117832-18-5) + 4-iodo-3-methoxy-phenylamine (1112840-98-8) + 2-iodo-5-methoxyaniline (153898-63-6) + 2-iodo-3-methoxyphenylamine (98991-09-4)

Guidance literature:

With N-iodo-succinimide; acetic acid; In benzene; at 20 ℃; for 72h; regioselective reaction;

DOI:10.1055/s-0031-1290118

Reference yield:

2-methoxy-4-nitrophenylamine (97-52-9) → 4-iodo-3-methoxy-phenylamine (1112840-98-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium nitrite; hydrogenchloride / water / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: ammonium chloride; iron / water; methanol; tetrahydrofuran / 4.5 h / 80 °C

With hydrogenchloride; iron; ammonium chloride; sodium nitrite; In tetrahydrofuran; methanol; water;

DOI:10.1248/cpb.c14-00333

Reference yield:

water (7732-18-5) + iodine (7553-56-2,12190-71-5,8031-47-8) + m-Anisidine (536-90-3,918666-97-4) → 4-iodo-3-methoxy-phenylamine (1112840-98-8)

Guidance literature:

DOI:10.1021/ja01367a042

upstream raw materials:

water

iodine

m-Anisidine

2-methoxy-4-nitrophenylamine

Refernces

• 1、 Numadate, Akiyoshi,Mita, Yusuke,Matsumoto, Yotaro,Fujii, Shinya,Hashimoto, Yuichi. "Development of 2-thioxoquinazoline-4-one derivatives as dual and selective inhibitors of dynamin-related protein 1 (Drp1) and puromycin-sensitive aminopeptidase (PSA)". . p. 979 - 988. Retrieved 2015/02/19.