Imipraminoxide

Base Information

• Chemical Name: Imipraminoxide
• CAS No.: 6829-98-7
• Deprecated CAS: 2207-85-4
• Molecular Formula: C19H24 N2 O
• Molecular Weight: 296.412
• European Community (EC) Number: 229-907-1
• UNII: 8MKS280XJW
• DSSTox Substance ID: DTXSID40218445
• Nikkaji Number: J9.848E
• Wikipedia: Imipraminoxide
• Wikidata: Q15409428
• NCI Thesaurus Code: C65897
• Metabolomics Workbench ID: 154562
• ChEMBL ID: CHEMBL1614644
• Mol file: 6829-98-7.mol

Synonyms:5-(3-(dimethylamino)propyl)-10,11-dihydro-5H- dibenz(b,f)azepine 5-(3-N-oxide);imipramine N-oxide;imipramine N-oxide hydrochloride;imipramine-N-oxide

Chemical Property of Imipraminoxide

Chemical Property:

• Melting Point: 93-95°C
• PSA: 32.67000
• LogP: 3.97350
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 296.188863393
• Heavy Atom Count: 22
• Complexity: 333

Purity/Quality:

98%Min ^*data from raw suppliers

Imipramine N-Oxide monohydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[N+](C)(CCCN1C2=CC=CC=C2CCC3=CC=CC=C31)[O-]
• Uses: Imipramine N-Oxide Monohydrate is a metabolite of Imipramine and is used as an antidepressant. Imipramine N-oxide is a metabolite of Imipramine. Used as an antidepressant

Technology Process of Imipraminoxide

There total 4 articles about Imipraminoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Imipramine hydrochloride (113-52-0) → 9,10-dihydrodibenzazepine (494-19-9) + imipramine N-oxide (6829-98-7)

Guidance literature:

In water; N,N-dimethyl-formamide; for 360h; Ambient temperature; F_. oxysporum f. sp. cepae (ATCC 11711); further microbial agents;

DOI:10.1002/jps.2600700209

Reference yield:

Imipramine hydrochloride (113-52-0) → 9,10-dihydrodibenzazepine (494-19-9) + 10-Hydroxyimipramine (796-28-1) + 2-hydroxyimipramine (303-70-8) + imipramine N-oxide (6829-98-7)

Guidance literature:

In water; N,N-dimethyl-formamide; for 480h; Further byproducts given; Ambient temperature; C_. blakesleeana (ATCC 8688a); further microbial agents;

DOI:10.1002/jps.2600700209

Reference yield:

impramine (50-49-7) → imipramine N-oxide (6829-98-7)

Guidance literature:

With dihydrogen peroxide; In methanol; for 168h;

DOI:10.1016/j.tetlet.2010.08.045

upstream raw materials:

Imipramine hydrochloride

impramine

Downstream raw materials:

impramine

Refernces

• 1、 Hufford,Capiton,Clark,Baker. "Metabolism of imipramine by microorganisms". . p. 151 - 155. Retrieved 2007/10/02.