Imipramine

Base Information Edit

Chemical Name:Imipramine
CAS No.:50-49-7
Molecular Formula:C19H24 N2
Molecular Weight:280.413
Hs Code.:2933990090
European Community (EC) Number:200-042-1
NSC Number:169866
UNII:OGG85SX4E4
DSSTox Substance ID:DTXSID1043881
Nikkaji Number:J8.587A
Wikipedia:Imipramine
Wikidata:Q58396
NCI Thesaurus Code:C62039
RXCUI:5691
Pharos Ligand ID:VV2MJKQ7KH9F
Metabolomics Workbench ID:37887
ChEMBL ID:CHEMBL11
Mol file:50-49-7.mol

Synonyms:4,4'-Methylenebis(3-hydroxy-2-naphthoic acid)-3-(10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)-N,N-dimethyl-1-propanamine (1:2);Imidobenzyle;Imipramine;Imipramine Hydrochloride;Imipramine Monohydrochloride;Imipramine Pamoate;Imizin;Janimine;Melipramine;Norchlorimipramine;Pryleugan;Tofranil

Suppliers and Price of Imipramine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Imipramine
500ul
$ 306.00

Matrix Scientific
3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine 95+%
1g
$ 240.00

Matrix Scientific
3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine 95+%
5g
$ 819.00

Crysdot
3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine 95+%
10g
$ 458.00

Chemtos
Imipraminelabeledd4Hydrochloride
10 mg
$ 1100.00

Chemtos
Imipramine-d4HCl0.1mg/ml
1ml of 0.1 mg
$ 50.00

American Custom Chemicals Corporation
IMIPRAMINE 95.00%
1G
$ 255.15

Alichem
3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
5g
$ 400.00

Total 60 raw suppliers

Chemical Property of Imipramine Edit

Chemical Property:

Vapor Pressure:1.04E-06mmHg at 25°C
Melting Point:174°C
Refractive Index:1.5640 (estimate)
Boiling Point:403.1°Cat760mmHg
PKA:pKa 9.66(H2O,t = 25,I=0.025) (Uncertain)
Flash Point:179.7°C
PSA：6.48000
Density:1.041g/cm³
LogP:3.94000
Water Solubility.:18.23mg/L(24 oC)
XLogP3:4.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:280.193948774
Heavy Atom Count:21
Complexity:291

Purity/Quality:

98% ^*data from raw suppliers

Imipramine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Drug Classes:Antidepressant Agents
Canonical SMILES:CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31
Recent ClinicalTrials:Therapeutic Efficacy in Women With Stress Urinary Incontinence
Recent EU Clinical Trials:Histological and clinical effects of Imipramine in the treatment of patients with cancer over-expressing Fascin1.
Uses Imipramine is used in depression of various etiology accompanied by motor clumsiness and enuresis in children and Parkinson’s disease. antidepressant
Therapeutic Function Antidepressant
Clinical Use Imipramine is a 10,11-dihydrodibenzazepine tertiary amine TCA that is marketed as hydrochloride and pamoate salts, both of which are administered orally. Although the hydrochloride salt may be administered in divided daily doses, imipramine's long duration of action suggests that the entire oral daily dose may be administered at one time.On the other hand, imipramine pamoate usually is administered as a single daily oral dose.

Technology Process of Imipramine

There total 17 articles about Imipramine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%