1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine

Base Information

• Chemical Name: 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine
• CAS No.: 1450657-31-4
• Molecular Formula: C₁₂H₁₇NO₄S
• Molecular Weight: 271.337
• Mol file: 1450657-31-4.mol

Synonyms:1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine

Chemical Property of 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine

Chemical Property:

Purity/Quality:

≥99.0% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine

There total 3 articles about 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)-ethylamine (608142-27-4) → 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethen-1-amine (1450657-31-4)

Guidance literature:

With N-acetylleucine; sode de l'acide trichloroisocyanurique; sodium hydroxide; In dichloromethane; water; at 25 ℃; for 0.75h; pH=8.9-9.5; Concentration; pH-value;

Reference yield:

3-ethoxy-4-hydroxybenzonitrile (60758-79-4) → 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethen-1-amine (1450657-31-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 4 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -5 - 0 °C

2.2: -5 - 30 °C

With n-butyllithium; potassium carbonate; In tetrahydrofuran; hexane; acetone;

Reference yield:

4-hydroxy-3-ethoxybenzaldehyde (121-32-4) → 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethen-1-amine (1450657-31-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride / acetonitrile / 4 h / Reflux

2.1: potassium carbonate / acetone / 4 h / Reflux

3.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -5 - 0 °C

3.2: -5 - 30 °C

With n-butyllithium; hydroxylamine hydrochloride; potassium carbonate; In tetrahydrofuran; hexane; acetone; acetonitrile;

upstream raw materials:

(R)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)-ethylamine

3-ethoxy-4-hydroxybenzonitrile

4-hydroxy-3-ethoxybenzaldehyde

Downstream raw materials:

2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine

C₁₂H₁₆⁽²⁾H₃NO₄S

C₁₂H₁₇⁽²⁾H₂NO₄S

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)[1-²H]ethanamine

Refernces

• 1、 -. "PROCESS FOR PREPARATION OF APREMILAST AND ITS INTERMEDIATES". Page/Page column 31; 32. . Retrieved 2016/12/26.