TERT-BUTYL 4-(N-HYDROXYCARBAMIMIDOYL)-PHENYLCARBAMATE

Base Information

• Chemical Name: TERT-BUTYL 4-(N-HYDROXYCARBAMIMIDOYL)-PHENYLCARBAMATE
• CAS No.: 918967-52-9
• Molecular Formula: C12H17N3O3
• Molecular Weight: 251.285
• Mol file: 918967-52-9.mol

Synonyms:TERT-BUTYL 4-(N-HYDROXYCARBAMIMIDOYL)-PHENYLCARBAMATE

Chemical Property of TERT-BUTYL 4-(N-HYDROXYCARBAMIMIDOYL)-PHENYLCARBAMATE

Chemical Property:

• PSA: 94.44000
• LogP: 2.90140

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-(N-hydroxycarbamimidoyl)-phenylcarbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 4-(N-HYDROXYCARBAMIMIDOYL)-PHENYLCARBAMATE

There total 6 articles about TERT-BUTYL 4-(N-HYDROXYCARBAMIMIDOYL)-PHENYLCARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

tert-butyl N-(4-cyanophenyl)carbamate (143090-18-0) → tert-butyl (4-(N’-hydroxycarbamimidoyl)phenyl)carbamate (918967-52-9)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydrogencarbonate; In ethanol; for 6h; Reflux;

DOI:10.1016/j.tetlet.2017.08.020

Reference yield:

tert-butyl N-(4-cyanophenyl)carbamate (143090-18-0) → tert-butyl [4-(N-hydroxycarbamimidoyl)phenyl]carbamate (918967-52-9)

Guidance literature:

With ammonium chloride; triethylamine; In ethanol; for 4h; Reflux;

Reference yield:

4-Aminobenzonitrile (873-74-5) → tert-butyl (4-(N’-hydroxycarbamimidoyl)phenyl)carbamate (918967-52-9)

Guidance literature:

Multi-step reaction with 3 steps

1: DMAP / tetrahydrofuran

2: NaOH / H₂O; tetrahydrofuran; ethanol

3: NH₂OH / H₂O; ethanol / 1.5 h / Heating

With dmap; sodium hydroxide; hydroxylamine; In tetrahydrofuran; ethanol; water;

DOI:10.1016/j.tetlet.2003.09.139

upstream raw materials:

tert-butyl N-(4-cyanophenyl)carbamate

4-Aminobenzonitrile

di-tert-butyl dicarbonate

Downstream raw materials:

4-(5-methyl-1,2,4-oxadiazol-3-yl)-aniline

[4-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-carbamic acid tert-butyl ester

[4-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-carbamic acid benzyl ester

4,5-dihydro-[1,2,4]oxadiazole

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS AS FUNGICIDES". Page/Page column 77. . Retrieved 2019/10/01.
• 2、 -. "Substituted Oxopyridine Derivatives and Use Thereof in the Treatment of Cardiovascular Disorders". Paragraph 0681-0684. . Retrieved 2016/05/02.