Pyridine, 4-(difluoromethyl)- (9CI)

Base Information

• Chemical Name: Pyridine, 4-(difluoromethyl)- (9CI)
• CAS No.: 82878-62-4
• Molecular Formula: C6H5F2N
• Molecular Weight: 129.109
• Hs Code.: 2933399090
• Mol file: 82878-62-4.mol

Synonyms:Pyridine, 4-(difluoromethyl)- (9CI);4-(Difluoromethyl)pyridine;alpha,alpha-Difluoro-4-picoline

Chemical Property of Pyridine, 4-(difluoromethyl)- (9CI)

Chemical Property:

• Refractive Index: n20/D 1.463
• Boiling Point: 165.6±30.0 °C(Predicted)
• PKA: 3.60±0.26(Predicted)
• Flash Point: 51°C
• PSA: 12.89000
• Density: 1.207g/mLat 25℃
• LogP: 2.01920

Purity/Quality:

98%min ^*data from raw suppliers

4-(Difluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 4-(difluoromethyl)- (9CI)

There total 1 articles about Pyridine, 4-(difluoromethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyridine (110-86-1) + Difluoroacetic acid (381-73-7) → 4-(difluoromethyl)pyridine (82878-62-4) + 2-(difluoromethyl)pyridine (114468-01-8) + 3-(difluoromethyl)pyridine (76541-44-1)

Guidance literature:

In acetonitrile; at 20 ℃; Reagent/catalyst; Overall yield = 85 %Spectr.; regioselective reaction; Catalytic behavior; Inert atmosphere; Electrolysis;

DOI:10.1039/c8dt01090k

Reference yield: 10.0%

4-(difluoromethyl)pyridine (82878-62-4) → 3-bromo-4-(difluoromethyl)pyridine (114468-05-2)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 168h; Heating;

upstream raw materials:

pyridine

Difluoroacetic acid

Downstream raw materials:

3-bromo-4-(difluoromethyl)pyridine

Refernces