Pyridine, 3-bromo-4-(difluoromethyl)- (9CI)

Base Information

• Chemical Name: Pyridine, 3-bromo-4-(difluoromethyl)- (9CI)
• CAS No.: 114468-05-2
• Molecular Formula: C₆H₄BrF₂N
• Molecular Weight: 208.005
• Hs Code.: 2933399990
• Mol file: 114468-05-2.mol

Synonyms:Pyridine, 3-bromo-4-(difluoromethyl)- (9CI)

Chemical Property of Pyridine, 3-bromo-4-(difluoromethyl)- (9CI)

Chemical Property:

• PSA: 12.89000
• LogP: 2.78170
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-Bromo-4-(difluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 3-bromo-4-(difluoromethyl)- (9CI)

There total 4 articles about Pyridine, 3-bromo-4-(difluoromethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-bromo-pyridine-4-carbaldehyde (70201-43-3) → 3-bromo-4-(difluoromethyl)pyridine (114468-05-2)

Guidance literature:

With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; at 0 ℃; for 2h;

Reference yield: 10.0%

4-(difluoromethyl)pyridine (82878-62-4) → 3-bromo-4-(difluoromethyl)pyridine (114468-05-2)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 168h; Heating;

Reference yield:

pyridine-4-carbaldehyde (872-85-5) → 3-bromo-4-(difluoromethyl)pyridine (114468-05-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 26 percent / SF₄, HF / 20 h / 120 °C

2: 10 percent / NBS, dibenzoylperoxide / CCl₄ / 168 h / Heating

With N-Bromosuccinimide; sulfur tetrafluoride; hydrogen fluoride; dibenzoyl peroxide; In tetrachloromethane;

upstream raw materials:

4-(difluoromethyl)pyridine

pyridine-4-carbaldehyde

3-bromo-pyridine-4-carbaldehyde

Refernces

• 1、 -. "6-AMINOPYRIDIN-3-YL PYRAZOLES AS MODULATORS OF RORgT". Paragraph 0370-0371. . Retrieved 2020/01/08.
• 2、 -. "IMIDAZOPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER". Paragraph 00274; 00279. . Retrieved 2018/04/12.