N-tert-butylfuran-2-carboxaMide

Base Information

• Chemical Name: N-tert-butylfuran-2-carboxaMide
• CAS No.: 98331-10-3
• Molecular Formula: C9H13NO2
• Molecular Weight: 167.208
• Mol file: 98331-10-3.mol

Synonyms:N-tert-butylfuran-2-carboxaMide

Chemical Property of N-tert-butylfuran-2-carboxaMide

Chemical Property:

• Melting Point: 100 - 102 °C
• PSA: 42.24000
• LogP: 2.19880
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

N-(tert-Butyl)furan-2-carboxamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-butylfuran-2-carboxaMide

There total 15 articles about N-tert-butylfuran-2-carboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

furfural (98-01-1) + acetic acid tert-butyl ester (540-88-5) → furan-2-carboxylic acid tert-butylamide (98331-10-3)

Guidance literature:

furfural; With sodium azide; trifluorormethanesulfonic acid; acetic acid; at 40 ℃; for 2h;

acetic acid tert-butyl ester; With trifluorormethanesulfonic acid; at 40 ℃;

DOI:10.1016/j.tetlet.2016.08.069

Reference yield: 92.0%

2-bromofuran (584-12-3) + tert-butylisonitrile (119072-55-8,7188-38-7) → furan-2-carboxylic acid tert-butylamide (98331-10-3)

Guidance literature:

With 4,5-dimethyl-1,3-bis-(2,4,6-trimethylphenyl)-3H-imidazol-1-ium chloride; water; nickel dibromide; sodium t-butanolate; In toluene; at 150 ℃; for 20h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tetlet.2020.152605

Reference yield: 92.0%

2-furancarbonitrile (617-90-3) + tert-butyl alcohol (75-65-0) → furan-2-carboxylic acid tert-butylamide (98331-10-3)

Guidance literature:

With 1-methyl-3-(4-sulfonylbutyl)-1H-imidazol-3-ium trifluoromethanesulfonate; at 50 ℃; for 4h; Inert atmosphere; Ionic liquid;

DOI:10.1016/j.tetlet.2010.12.028

upstream raw materials:

2-furancarbonyl chloride

tert-butylamine

(E)-1-iodo-3-pentene

2-furoyl azide

Refernces

• 1、 Samanta, Samya,Shah, Sk. Sheriff,Shee, Maniklal,Singh, Amit Kumar,Singh, N. D. Pradeep,Venkatesh, Yarra. "Organophotoredox-Mediated Amide Synthesis by Coupling Alcohol and Amine through Aerobic Oxidation of Alcohol". supporting information. . Retrieved 2020/03/05.
• 2、 Li, Qiao,Cai, Yun,Jin, Hongwei,Liu, Yunkui,Zhou, Bingwei. "Nickel-catalyzed aminocarbonylation of Aryl/Alkenyl/Allyl (pseudo)halides with isocyanides and H2O". supporting information. . Retrieved 2020/11/27.