3-keto cyclopentanone acetal

Base Information

• Chemical Name: 3-keto cyclopentanone acetal
• CAS No.: 109459-59-8
• Molecular Formula: C7H10O3
• Molecular Weight: 142.155
• Mol file: 109459-59-8.mol

Synonyms:3-keto cyclopentanone acetal

Chemical Property of 3-keto cyclopentanone acetal

Chemical Property:

• Boiling Point: 244.1±25.0 °C(Predicted)
• PSA: 35.53000
• Density: 1.21±0.1 g/cm3(Predicted)
• LogP: 0.48250

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,4-Dioxaspiro[4.4]nonan-7-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-keto cyclopentanone acetal

There total 3 articles about 3-keto cyclopentanone acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-hydroxy-cyclopentanone ethylene acetal (109459-57-6) → 1,4-dioxaspiro[4.4]nonan-7-one (109459-59-8)

Guidance literature:

With pyridine; chromium(III) oxide; kieselguhr; In dichloromethane; for 0.333333h; Ambient temperature;

DOI:10.1016/S0040-4039(00)95779-4

Reference yield:

1,4-dioxaspiro[4.4]non-6-ene (695-56-7) → 1,4-dioxaspiro[4.4]nonan-7-one (109459-59-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) HBr, 2.) NaH / 2.) THF

2: 81 percent / LiAlH₄ / tetrahydrofuran / 24 h / Heating

3: 85 percent / pyridine, Cr₂O₃, kieselguhr / CH₂Cl₂ / 0.33 h / Ambient temperature

With pyridine; chromium(III) oxide; lithium aluminium tetrahydride; kieselguhr; hydrogen bromide; sodium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(00)95779-4

Reference yield:

6,7-epoxy-1,4-dioxa-spiro[4.4]nonane (36341-49-8,319491-92-4) → 1,4-dioxaspiro[4.4]nonan-7-one (109459-59-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / LiAlH₄ / tetrahydrofuran / 24 h / Heating

2: 85 percent / pyridine, Cr₂O₃, kieselguhr / CH₂Cl₂ / 0.33 h / Ambient temperature

With pyridine; chromium(III) oxide; lithium aluminium tetrahydride; kieselguhr; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(00)95779-4

upstream raw materials:

3-hydroxy-cyclopentanone ethylene acetal

1,4-dioxaspiro[4.4]non-6-ene

6,7-epoxy-1,4-dioxa-spiro[4.4]nonane

Downstream raw materials:

1,3-cyclopentadione

Refernces