3-hydroxy-cyclopentanone ethylene acetal

Base Information

• Chemical Name: 3-hydroxy-cyclopentanone ethylene acetal
• CAS No.: 109459-57-6
• Molecular Formula: C₇H₁₂O₃
• Molecular Weight: 144.17
• Mol file: 109459-57-6.mol

Synonyms:3-hydroxy-cyclopentanone ethylene acetal

Chemical Property of 3-hydroxy-cyclopentanone ethylene acetal

Chemical Property:

• Boiling Point: 100 °C(Press: 4 Torr)
• Density: 1.21±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

1,4-Dioxaspiro[4.4]nonan-7-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-hydroxy-cyclopentanone ethylene acetal

There total 3 articles about 3-hydroxy-cyclopentanone ethylene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

6,7-epoxy-1,4-dioxa-spiro[4.4]nonane (36341-49-8,319491-92-4) → 3-hydroxy-cyclopentanone ethylene acetal (109459-57-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 24h; Heating;

DOI:10.1016/S0040-4039(00)95779-4

Reference yield: 76.0%

6-Bromo-1,4-dioxa-spiro[4.4]nonan-7-ol → 3-hydroxy-cyclopentanone ethylene acetal (109459-57-6)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; for 2h; Heating;

DOI:10.1016/S0040-4020(01)85714-8

Reference yield:

1,4-dioxaspiro[4.4]non-6-ene (695-56-7) → 3-hydroxy-cyclopentanone ethylene acetal (109459-57-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / N-bromosuccinimide / dimethylsulfoxide; H₂O / 10 °C

2: 76 percent / tributyltinhydride, AIBN / benzene / 2 h / Heating

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In water; dimethyl sulfoxide; benzene;

DOI:10.1016/S0040-4020(01)85714-8

upstream raw materials:

6,7-epoxy-1,4-dioxa-spiro[4.4]nonane

1,4-dioxaspiro[4.4]non-6-ene

Downstream raw materials:

1,4-dioxaspiro[4.4]nonan-7-one

1,3-cyclopentadione

Refernces

• 1、 Vankar, Yashwant D.,Chaudhuri, Narayan C.,Rao, C. Trinadha. "REGIOSELECTIVE REDUCTIONS OF 2,3-EPOXY ACETALS WITH ZINC-CHLOROTRIMETHYLSILANE AND LITHIUM ALUMINIUM HYDRIDE: CONVENIENT SYNTHESIS OF 1,2 AND 1,3-DIONES". . p. 551 - 554. Retrieved 2007/10/02.